Primary headache and epilepsy: A multicenter cross-sectional study

M. C. Tonini, L. Giordano, L. Atzeni, G. Bogliun, G. Perri, M. G. Saracco, M. Tombini, P. Torelli, M. Turazzini, F. Vernieri, M. Aguggia, G. Bussone, E. Beghi, G. Saracco, V. Montano, R. De Marco, G. Chiodelli, G. Perri, G. Colturami, R. SpagliardiE. Vitelli, N. Massetto, M. P. Canevini, B. Colombo, L. Bernasconi, P. Annovazzi, F. Minicucci, L. Atzeni, G. Bogliun, E. Sasso, F. Vernieri, M. Tombini, L. Pacifici

Research output: Contribution to journalArticlepeer-review


The prevalence and characteristics of interictal headache, epilepsy and headache/epilepsy comorbidity were assessed in 858 women and 309 men aged 18-81. years from headache and epilepsy centers in Italy. The research hypothesis was that comorbidity among patients with either disorder would be expected to be higher than in the general population.Interictal headache was diagnosed in 675 cases (migraine 482; tension-type headache 168; other types 25), epilepsy in 336 (partial 171; generalized 165) and comorbidity in 156 (1.6% from headache centers; 30.0% from epilepsy centers). Patients with epilepsy, headache and comorbidity differed in a number of demographic and clinical aspects. However, for both headache and epilepsy, a family history of the same clinical condition was equally prevalent in patients with and without comorbidity. These findings do not support the purported association between headache and epilepsy.

Original languageEnglish
Pages (from-to)342-347
Number of pages6
JournalEpilepsy and Behavior
Issue number3
Publication statusPublished - Mar 1 2012


  • Comorbidity
  • Epidemiology
  • Epilepsy
  • Headache
  • Migraine
  • Tension-type headache

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology


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