Abstract
In the absence of any antiretroviral therapy, about one-third of infants with perinatally acquired HIV infection develop AIDS within the first months of life, while the remainder show slower disease progression. As the rate of viral replication during the first 3 months of life is strictly correlated with and predictive of disease outcome, any treatment that keeps the virus at low levels during primary infection might substantially modify the natural history of infection. Emerging data show that some infants treated early with highly active antiretroviral therapy have persistenty undetectable levels of HIV, and lack an HIV-specific immune response, despite preservation of immune functions. These findings strongly suggest that early therapeutic intervention might lead to a long-term suppression of viral replication.
| Original language | English |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 16 |
| Issue number | 1 |
| Publication status | Published - 2002 |
Fingerprint
Keywords
- Highly active antiretroviral therapy
- HIV perinatal transmission
- Primary infection
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Endocrinology
- Physiology
- Immunology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)
Cite this
Primary HIV infection in infants : Impact of highly active antiretroviral therapy on the natural course. / De Rossi, A.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 16, No. 1, 2002, p. 53-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary HIV infection in infants
T2 - Impact of highly active antiretroviral therapy on the natural course
AU - De Rossi, A.
PY - 2002
Y1 - 2002
N2 - In the absence of any antiretroviral therapy, about one-third of infants with perinatally acquired HIV infection develop AIDS within the first months of life, while the remainder show slower disease progression. As the rate of viral replication during the first 3 months of life is strictly correlated with and predictive of disease outcome, any treatment that keeps the virus at low levels during primary infection might substantially modify the natural history of infection. Emerging data show that some infants treated early with highly active antiretroviral therapy have persistenty undetectable levels of HIV, and lack an HIV-specific immune response, despite preservation of immune functions. These findings strongly suggest that early therapeutic intervention might lead to a long-term suppression of viral replication.
AB - In the absence of any antiretroviral therapy, about one-third of infants with perinatally acquired HIV infection develop AIDS within the first months of life, while the remainder show slower disease progression. As the rate of viral replication during the first 3 months of life is strictly correlated with and predictive of disease outcome, any treatment that keeps the virus at low levels during primary infection might substantially modify the natural history of infection. Emerging data show that some infants treated early with highly active antiretroviral therapy have persistenty undetectable levels of HIV, and lack an HIV-specific immune response, despite preservation of immune functions. These findings strongly suggest that early therapeutic intervention might lead to a long-term suppression of viral replication.
KW - Highly active antiretroviral therapy
KW - HIV perinatal transmission
KW - Primary infection
UR - http://www.scopus.com/inward/record.url?scp=0036255711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036255711&partnerID=8YFLogxK
M3 - Article
C2 - 12003175
AN - SCOPUS:0036255711
VL - 16
SP - 53
EP - 57
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
SN - 0393-974X
IS - 1
ER -