Primary human herpesvirus 8 infection in immunocompetent children

Massimo Andreoni, Loredana Sarmati, Emanuele Nicastri, Gamal El Sawaf, Mahmoud El Zalabani, Ilaria Uccella, Roberto Bugarini, Saverio G. Parisi, Giovanni Rezza

Research output: Contribution to journalArticlepeer-review


Context: Human herpesvirus 8 (HHV-8) infection causes Kaposi sarcoma and lymphoproliferative disorders in immunosuppressed adults. Its manifestations in immunocompetent hosts are unknown. Objectives: To determine whether HHV-8 primary infection is symptomatic in immunocompetent children and to identify the epidemiological and virological correlates of HHV-8 infection. Design and Setting: Prospective cohort study conducted in the pediatric emergency department of a hospital in Alexandria, Egypt, between December 1, 1999, and April 30, 2000. Patients: Eighty-six children aged 1 to 4 years who were evaluated for a febrile syndrome of undetermined origin. Main Outcome Measures: Serological assay and polymerase chain reaction of blood and saliva samples for HHV-8. Information on potential risk factors for HHV-8 infection was also collected. Results: Thirty-six children (41.9%) were seropositive; HHV-8 DNA sequences were detected in 14 (38.9%) of these 36 children (detected in saliva in 11 of 14). Significant associations were found between HHV-8 infection and close contact with at least 2 other children in the community (36 of 63 vs 6 of 23 for

Original languageEnglish
Pages (from-to)1295-1300
Number of pages6
JournalJournal of the American Medical Association
Issue number10
Publication statusPublished - Mar 13 2002

ASJC Scopus subject areas

  • Medicine(all)


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