TY - JOUR
T1 - Primary human herpesvirus 8 infection in immunocompetent children
AU - Andreoni, Massimo
AU - Sarmati, Loredana
AU - Nicastri, Emanuele
AU - Sawaf, Gamal El
AU - Zalabani, Mahmoud El
AU - Uccella, Ilaria
AU - Bugarini, Roberto
AU - Parisi, Saverio G.
AU - Rezza, Giovanni
PY - 2002/3/13
Y1 - 2002/3/13
N2 - Context: Human herpesvirus 8 (HHV-8) infection causes Kaposi sarcoma and lymphoproliferative disorders in immunosuppressed adults. Its manifestations in immunocompetent hosts are unknown. Objectives: To determine whether HHV-8 primary infection is symptomatic in immunocompetent children and to identify the epidemiological and virological correlates of HHV-8 infection. Design and Setting: Prospective cohort study conducted in the pediatric emergency department of a hospital in Alexandria, Egypt, between December 1, 1999, and April 30, 2000. Patients: Eighty-six children aged 1 to 4 years who were evaluated for a febrile syndrome of undetermined origin. Main Outcome Measures: Serological assay and polymerase chain reaction of blood and saliva samples for HHV-8. Information on potential risk factors for HHV-8 infection was also collected. Results: Thirty-six children (41.9%) were seropositive; HHV-8 DNA sequences were detected in 14 (38.9%) of these 36 children (detected in saliva in 11 of 14). Significant associations were found between HHV-8 infection and close contact with at least 2 other children in the community (36 of 63 vs 6 of 23 for
AB - Context: Human herpesvirus 8 (HHV-8) infection causes Kaposi sarcoma and lymphoproliferative disorders in immunosuppressed adults. Its manifestations in immunocompetent hosts are unknown. Objectives: To determine whether HHV-8 primary infection is symptomatic in immunocompetent children and to identify the epidemiological and virological correlates of HHV-8 infection. Design and Setting: Prospective cohort study conducted in the pediatric emergency department of a hospital in Alexandria, Egypt, between December 1, 1999, and April 30, 2000. Patients: Eighty-six children aged 1 to 4 years who were evaluated for a febrile syndrome of undetermined origin. Main Outcome Measures: Serological assay and polymerase chain reaction of blood and saliva samples for HHV-8. Information on potential risk factors for HHV-8 infection was also collected. Results: Thirty-six children (41.9%) were seropositive; HHV-8 DNA sequences were detected in 14 (38.9%) of these 36 children (detected in saliva in 11 of 14). Significant associations were found between HHV-8 infection and close contact with at least 2 other children in the community (36 of 63 vs 6 of 23 for
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M3 - Article
C2 - 11886321
AN - SCOPUS:0037070529
VL - 287
SP - 1295
EP - 1300
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 10
ER -