Abstract
Fibrinolysis is a complex process that controls both hemostasis and thrombosis. The regulation of the fibrinolytic system is mediated through a wide array of cofactors and inhibitors that maintain the hemostatic balance in a delicate equilibrium. As a consequence, disturbances in the fibrinolysis pathway are associated with various disease states, ranging from thrombotic to hemorrhagic clinical phenotypes. In particular, a number of inherited and acquired disorders are associated with an enhanced fibrinolysis leading to a bleeding tendency that in some cases may be life-threatening. Hyperfibrinolysis has been classified into primary and secondary forms but such differentiation, which may have important treatment implications, is still controversial. This narrative review will be focused on inherited and acquired conditions associated with primary hyperfibrinolysis.
| Original language | English |
|---|---|
| Pages (from-to) | 71-75 |
| Number of pages | 5 |
| Journal | Thrombosis Research |
| Volume | 166 |
| DOIs | |
| Publication status | Published - Jun 1 2018 |
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Keywords
- Acquired
- Antifibrinolytics
- Bleeding
- Inherited
- Primary hyperfibrinolysis
ASJC Scopus subject areas
- Hematology
Cite this
Primary hyperfibrinolysis : Facts and fancies. / Franchini, Massimo; Mannucci, Pier Mannuccio.
In: Thrombosis Research, Vol. 166, 01.06.2018, p. 71-75.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Primary hyperfibrinolysis
T2 - Facts and fancies
AU - Franchini, Massimo
AU - Mannucci, Pier Mannuccio
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Fibrinolysis is a complex process that controls both hemostasis and thrombosis. The regulation of the fibrinolytic system is mediated through a wide array of cofactors and inhibitors that maintain the hemostatic balance in a delicate equilibrium. As a consequence, disturbances in the fibrinolysis pathway are associated with various disease states, ranging from thrombotic to hemorrhagic clinical phenotypes. In particular, a number of inherited and acquired disorders are associated with an enhanced fibrinolysis leading to a bleeding tendency that in some cases may be life-threatening. Hyperfibrinolysis has been classified into primary and secondary forms but such differentiation, which may have important treatment implications, is still controversial. This narrative review will be focused on inherited and acquired conditions associated with primary hyperfibrinolysis.
AB - Fibrinolysis is a complex process that controls both hemostasis and thrombosis. The regulation of the fibrinolytic system is mediated through a wide array of cofactors and inhibitors that maintain the hemostatic balance in a delicate equilibrium. As a consequence, disturbances in the fibrinolysis pathway are associated with various disease states, ranging from thrombotic to hemorrhagic clinical phenotypes. In particular, a number of inherited and acquired disorders are associated with an enhanced fibrinolysis leading to a bleeding tendency that in some cases may be life-threatening. Hyperfibrinolysis has been classified into primary and secondary forms but such differentiation, which may have important treatment implications, is still controversial. This narrative review will be focused on inherited and acquired conditions associated with primary hyperfibrinolysis.
KW - Acquired
KW - Antifibrinolytics
KW - Bleeding
KW - Inherited
KW - Primary hyperfibrinolysis
UR - http://www.scopus.com/inward/record.url?scp=85045537809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045537809&partnerID=8YFLogxK
U2 - 10.1016/j.thromres.2018.04.010
DO - 10.1016/j.thromres.2018.04.010
M3 - Review article
C2 - 29665524
AN - SCOPUS:85045537809
VL - 166
SP - 71
EP - 75
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
ER -