Abstract
A 67-year-old female was admitted to our department with difficulty in speech, disorientation, memory loss and seizures. Blood laboratory tests revealed diabetes insipidus. This patient had been treated with steroids for systemic lupus erythematosus (SLE) for 30 years. Due to this treatment neurological symptoms had been understated causing a long delay in performing ulterior researches. A brain MRI revealed a mass lesion in the hypothalamic area. A biopsy was performed and histopathological diagnosis was malignant large B cell lymphoma. Subsequently, she received methotrexate therapy but died of pneumonia during the second cycle. Primary central nervous system lymphoma in association with SLE is a rare occurrence but it should be considered in the diagnostic process when neurological symptoms occur. A brain MRI must be performed and corticosteroids should be interrupted. A biopsy of the cerebral mass lesion permits diagnosis and appropriate therapy may be administered.
| Original language | English |
|---|---|
| Pages (from-to) | 647-652 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2010 |
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Keywords
- Hypothalamus
- Lymphoma
- Primary central nervous system
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Primary hypothalamic lymphoma in a patient with systemic lupus erythematosus : Case report and review of the literature. / Biasiotta, Antonella; Frati, Alessandro; Salvati, Maurizio; Raco, Antonino; Fazi, Maurizio; D'Elia, Alessandro; Cruccu, Giorgio.
In: Neurological Sciences, Vol. 31, No. 5, 10.2010, p. 647-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary hypothalamic lymphoma in a patient with systemic lupus erythematosus
T2 - Case report and review of the literature
AU - Biasiotta, Antonella
AU - Frati, Alessandro
AU - Salvati, Maurizio
AU - Raco, Antonino
AU - Fazi, Maurizio
AU - D'Elia, Alessandro
AU - Cruccu, Giorgio
PY - 2010/10
Y1 - 2010/10
N2 - A 67-year-old female was admitted to our department with difficulty in speech, disorientation, memory loss and seizures. Blood laboratory tests revealed diabetes insipidus. This patient had been treated with steroids for systemic lupus erythematosus (SLE) for 30 years. Due to this treatment neurological symptoms had been understated causing a long delay in performing ulterior researches. A brain MRI revealed a mass lesion in the hypothalamic area. A biopsy was performed and histopathological diagnosis was malignant large B cell lymphoma. Subsequently, she received methotrexate therapy but died of pneumonia during the second cycle. Primary central nervous system lymphoma in association with SLE is a rare occurrence but it should be considered in the diagnostic process when neurological symptoms occur. A brain MRI must be performed and corticosteroids should be interrupted. A biopsy of the cerebral mass lesion permits diagnosis and appropriate therapy may be administered.
AB - A 67-year-old female was admitted to our department with difficulty in speech, disorientation, memory loss and seizures. Blood laboratory tests revealed diabetes insipidus. This patient had been treated with steroids for systemic lupus erythematosus (SLE) for 30 years. Due to this treatment neurological symptoms had been understated causing a long delay in performing ulterior researches. A brain MRI revealed a mass lesion in the hypothalamic area. A biopsy was performed and histopathological diagnosis was malignant large B cell lymphoma. Subsequently, she received methotrexate therapy but died of pneumonia during the second cycle. Primary central nervous system lymphoma in association with SLE is a rare occurrence but it should be considered in the diagnostic process when neurological symptoms occur. A brain MRI must be performed and corticosteroids should be interrupted. A biopsy of the cerebral mass lesion permits diagnosis and appropriate therapy may be administered.
KW - Hypothalamus
KW - Lymphoma
KW - Primary central nervous system
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=78049331352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049331352&partnerID=8YFLogxK
U2 - 10.1007/s10072-010-0338-x
DO - 10.1007/s10072-010-0338-x
M3 - Article
VL - 31
SP - 647
EP - 652
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 5
ER -