Abstract
Introduction: Primary fibrosarcomas of the brain are very rare tumors, so that information regarding the treatment is scarce. We report the contributions that different therapeutic options made to the treatment of a child with one of these aggressive tumors. Case report: A 13-year-old boy underwent a complete resection of a left temporo-parietal mass that had been diagnosed as a fibrosarcoma by two independent pathologists. Adjuvant chemotherapy with vincristine, actinomycin-D, ifosfamide and Adriamycin was started, but after 3 months tumor relapse was evident. The boy subsequently received radiation therapy during which there was evidence of progressive tumor shrinkage. A second surgery was performed 6 months after radiotherapy and a small enhancing lesion, revealed to be gliosis, was resected. The child remains alive and well 44 months after diagnosis. Conclusion: Our experience supports the importance of total resection followed by radiation therapy, and radiotherapy should be started as soon as possible after surgical resection, rather than administering chemotherapy first.
| Original language | English |
|---|---|
| Pages (from-to) | 648-651 |
| Number of pages | 4 |
| Journal | Child's Nervous System |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2002 |
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Keywords
- Fibrosarcoma
- Intracranial sarcoma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology
Cite this
Primary intracranial fibrosarcoma. / Bisogno, Gianni; Roganovic, Jelena; Carli, Modesto; Scarzello, Giovanni; Calderone, Milena; Faggin, Roberto; Perilongo, Giorgio.
In: Child's Nervous System, Vol. 18, No. 11, 01.11.2002, p. 648-651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary intracranial fibrosarcoma
AU - Bisogno, Gianni
AU - Roganovic, Jelena
AU - Carli, Modesto
AU - Scarzello, Giovanni
AU - Calderone, Milena
AU - Faggin, Roberto
AU - Perilongo, Giorgio
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Introduction: Primary fibrosarcomas of the brain are very rare tumors, so that information regarding the treatment is scarce. We report the contributions that different therapeutic options made to the treatment of a child with one of these aggressive tumors. Case report: A 13-year-old boy underwent a complete resection of a left temporo-parietal mass that had been diagnosed as a fibrosarcoma by two independent pathologists. Adjuvant chemotherapy with vincristine, actinomycin-D, ifosfamide and Adriamycin was started, but after 3 months tumor relapse was evident. The boy subsequently received radiation therapy during which there was evidence of progressive tumor shrinkage. A second surgery was performed 6 months after radiotherapy and a small enhancing lesion, revealed to be gliosis, was resected. The child remains alive and well 44 months after diagnosis. Conclusion: Our experience supports the importance of total resection followed by radiation therapy, and radiotherapy should be started as soon as possible after surgical resection, rather than administering chemotherapy first.
AB - Introduction: Primary fibrosarcomas of the brain are very rare tumors, so that information regarding the treatment is scarce. We report the contributions that different therapeutic options made to the treatment of a child with one of these aggressive tumors. Case report: A 13-year-old boy underwent a complete resection of a left temporo-parietal mass that had been diagnosed as a fibrosarcoma by two independent pathologists. Adjuvant chemotherapy with vincristine, actinomycin-D, ifosfamide and Adriamycin was started, but after 3 months tumor relapse was evident. The boy subsequently received radiation therapy during which there was evidence of progressive tumor shrinkage. A second surgery was performed 6 months after radiotherapy and a small enhancing lesion, revealed to be gliosis, was resected. The child remains alive and well 44 months after diagnosis. Conclusion: Our experience supports the importance of total resection followed by radiation therapy, and radiotherapy should be started as soon as possible after surgical resection, rather than administering chemotherapy first.
KW - Fibrosarcoma
KW - Intracranial sarcoma
UR - http://www.scopus.com/inward/record.url?scp=0036864556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036864556&partnerID=8YFLogxK
U2 - 10.1007/s00381-002-0628-6
DO - 10.1007/s00381-002-0628-6
M3 - Article
C2 - 12420128
AN - SCOPUS:0036864556
VL - 18
SP - 648
EP - 651
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 11
ER -