Abstract
Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 722-728 |
| Number of pages | 7 |
| Journal | American Journal of Clinical Pathology |
| Volume | 94 |
| Issue number | 6 |
| Publication status | Published - 1990 |
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Keywords
- CNS lymphoma
- Epstein-Barr Virus [EBV]
- Pediatric AIDS
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. / Del Mistro, A.; Laverda, A.; Calabrese, F.; De Martino, M.; Calabri, G.; Cogo, P.; Cocchi, P.; D'Andrea, E.; De Rossi, A.; Giaquinto, C.; Giordano, R.; Nieri, R. M.; Salvi, G.; Pennelli, N.; Chieco-Bianchi, L.
In: American Journal of Clinical Pathology, Vol. 94, No. 6, 1990, p. 722-728.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome
AU - Del Mistro, A.
AU - Laverda, A.
AU - Calabrese, F.
AU - De Martino, M.
AU - Calabri, G.
AU - Cogo, P.
AU - Cocchi, P.
AU - D'Andrea, E.
AU - De Rossi, A.
AU - Giaquinto, C.
AU - Giordano, R.
AU - Nieri, R. M.
AU - Salvi, G.
AU - Pennelli, N.
AU - Chieco-Bianchi, L.
PY - 1990
Y1 - 1990
N2 - Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.
AB - Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.
KW - CNS lymphoma
KW - Epstein-Barr Virus [EBV]
KW - Pediatric AIDS
UR - http://www.scopus.com/inward/record.url?scp=0025607094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025607094&partnerID=8YFLogxK
M3 - Article
C2 - 2173885
AN - SCOPUS:0025607094
VL - 94
SP - 722
EP - 728
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 6
ER -