Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome

A. Del Mistro, A. Laverda, F. Calabrese, M. De Martino, G. Calabri, P. Cogo, P. Cocchi, E. D'Andrea, A. De Rossi, C. Giaquinto, R. Giordano, R. M. Nieri, G. Salvi, N. Pennelli, L. Chieco-Bianchi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.

Original languageEnglish
Pages (from-to)722-728
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume94
Issue number6
Publication statusPublished - 1990

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Human Herpesvirus 4
Lymphoma
Acquired Immunodeficiency Syndrome
B-Lymphocytes
Central Nervous System
Immunoglobulin Genes
Epstein-Barr Virus Infections
Gene Rearrangement
Non-Hodgkin's Lymphoma
Autopsy
Immunohistochemistry
Cell Proliferation
Genome

Keywords

  • CNS lymphoma
  • Epstein-Barr Virus [EBV]
  • Pediatric AIDS

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Del Mistro, A., Laverda, A., Calabrese, F., De Martino, M., Calabri, G., Cogo, P., ... Chieco-Bianchi, L. (1990). Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. American Journal of Clinical Pathology, 94(6), 722-728.

Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. / Del Mistro, A.; Laverda, A.; Calabrese, F.; De Martino, M.; Calabri, G.; Cogo, P.; Cocchi, P.; D'Andrea, E.; De Rossi, A.; Giaquinto, C.; Giordano, R.; Nieri, R. M.; Salvi, G.; Pennelli, N.; Chieco-Bianchi, L.

In: American Journal of Clinical Pathology, Vol. 94, No. 6, 1990, p. 722-728.

Research output: Contribution to journalArticle

Del Mistro, A, Laverda, A, Calabrese, F, De Martino, M, Calabri, G, Cogo, P, Cocchi, P, D'Andrea, E, De Rossi, A, Giaquinto, C, Giordano, R, Nieri, RM, Salvi, G, Pennelli, N & Chieco-Bianchi, L 1990, 'Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome', American Journal of Clinical Pathology, vol. 94, no. 6, pp. 722-728.
Del Mistro, A. ; Laverda, A. ; Calabrese, F. ; De Martino, M. ; Calabri, G. ; Cogo, P. ; Cocchi, P. ; D'Andrea, E. ; De Rossi, A. ; Giaquinto, C. ; Giordano, R. ; Nieri, R. M. ; Salvi, G. ; Pennelli, N. ; Chieco-Bianchi, L. / Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. In: American Journal of Clinical Pathology. 1990 ; Vol. 94, No. 6. pp. 722-728.
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AU - Laverda, A.

AU - Calabrese, F.

AU - De Martino, M.

AU - Calabri, G.

AU - Cogo, P.

AU - Cocchi, P.

AU - D'Andrea, E.

AU - De Rossi, A.

AU - Giaquinto, C.

AU - Giordano, R.

AU - Nieri, R. M.

AU - Salvi, G.

AU - Pennelli, N.

AU - Chieco-Bianchi, L.

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AB - Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.

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