Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome

A. Del Mistro; A. Laverda; F. Calabrese; M. De Martino; G. Calabri; P. Cogo; P. Cocchi; E. D'Andrea; A. De Rossi; C. Giaquinto; R. Giordano; R. M. Nieri; G. Salvi; N. Pennelli; L. Chieco-Bianchi

Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome

A. Del Mistro, A. Laverda, F. Calabrese, M. De Martino, G. Calabri, P. Cogo, P. Cocchi, E. D'Andrea, A. De Rossi, C. Giaquinto, R. Giordano, R. M. Nieri, G. Salvi, N. Pennelli, L. Chieco-Bianchi

Research output: Contribution to journal › Article › peer-review

Abstract

Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.

Original language	English
Pages (from-to)	722-728
Number of pages	7
Journal	American Journal of Clinical Pathology
Volume	94
Issue number	6
Publication status	Published - 1990

Keywords

CNS lymphoma
Epstein-Barr Virus [EBV]
Pediatric AIDS

ASJC Scopus subject areas

Pathology and Forensic Medicine

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Del Mistro, A., Laverda, A., Calabrese, F., De Martino, M., Calabri, G., Cogo, P., Cocchi, P., D'Andrea, E., De Rossi, A., Giaquinto, C., Giordano, R., Nieri, R. M., Salvi, G., Pennelli, N., & Chieco-Bianchi, L. (1990). Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. American Journal of Clinical Pathology, 94(6), 722-728.

Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. / Del Mistro, A.; Laverda, A.; Calabrese, F.; De Martino, M.; Calabri, G.; Cogo, P.; Cocchi, P.; D'Andrea, E.; De Rossi, A.; Giaquinto, C.; Giordano, R.; Nieri, R. M.; Salvi, G.; Pennelli, N.; Chieco-Bianchi, L.

In: American Journal of Clinical Pathology, Vol. 94, No. 6, 1990, p. 722-728.

Research output: Contribution to journal › Article › peer-review

Del Mistro, A, Laverda, A, Calabrese, F, De Martino, M, Calabri, G, Cogo, P, Cocchi, P, D'Andrea, E, De Rossi, A, Giaquinto, C, Giordano, R, Nieri, RM, Salvi, G, Pennelli, N & Chieco-Bianchi, L 1990, 'Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome', American Journal of Clinical Pathology, vol. 94, no. 6, pp. 722-728.

Del Mistro, A. ; Laverda, A. ; Calabrese, F. ; De Martino, M. ; Calabri, G. ; Cogo, P. ; Cocchi, P. ; D'Andrea, E. ; De Rossi, A. ; Giaquinto, C. ; Giordano, R. ; Nieri, R. M. ; Salvi, G. ; Pennelli, N. ; Chieco-Bianchi, L. / Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome. In: American Journal of Clinical Pathology. 1990 ; Vol. 94, No. 6. pp. 722-728.

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title = "Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome",

abstract = "Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.",

keywords = "CNS lymphoma, Epstein-Barr Virus [EBV], Pediatric AIDS",

author = "{Del Mistro}, A. and A. Laverda and F. Calabrese and {De Martino}, M. and G. Calabri and P. Cogo and P. Cocchi and E. D'Andrea and {De Rossi}, A. and C. Giaquinto and R. Giordano and Nieri, {R. M.} and G. Salvi and N. Pennelli and L. Chieco-Bianchi",

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T1 - Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome

AU - Del Mistro, A.

AU - Laverda, A.

AU - Calabrese, F.

AU - De Martino, M.

AU - Calabri, G.

AU - Cogo, P.

AU - Cocchi, P.

AU - D'Andrea, E.

AU - De Rossi, A.

AU - Giaquinto, C.

AU - Giordano, R.

AU - Nieri, R. M.

AU - Salvi, G.

AU - Pennelli, N.

AU - Chieco-Bianchi, L.

PY - 1990

Y1 - 1990

N2 - Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.

AB - Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.

KW - CNS lymphoma

KW - Epstein-Barr Virus [EBV]

KW - Pediatric AIDS

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IS - 6

ER -

Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome

Abstract

Keywords

ASJC Scopus subject areas

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