Primary malignant melanoma arising in the parotid gland: Case report and literature review

Mario Bussi, Laura Cardarelli, Elena Riontino, Guido Valente

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Melanoma of the head and neck is an extremely rare disease, characterized by difficult and late diagnosis and poor prognosis; moreover, the definition of primary melanomas of the salivary glands remains controversial. In this paper we describe an unusual case of primary melanoma arising in the parotid gland. A 60-year-old woman presented to us for the persistence of a parotid neoplasm diagnosed as carcinoma by fine-needle aspiration and treated with radiation therapy. Wide destructive surgery was performed and immunohistochemical analysis of the surgical specimen led to a diagnosis of melanoma. Complete screening excluded other primary tumor sites. After five years of follow-up the patient is alive and free of disease. Here we report the diagnostic procedures leading to the diagnosis along with a critical analysis of the literature, emphasizing the difficulties in the diagnosis and classification of melanoma as a primary tumor in the parotid gland and the need for destructive surgery.

Original languageEnglish
Pages (from-to)523-525
Number of pages3
Issue number6
Publication statusPublished - Nov 1999


  • Parotid gland
  • Primary malignant melanoma

ASJC Scopus subject areas

  • Cancer Research


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