Primary malignant melanoma of the esophagus

A clinicopathologic study of a case with comprehensive literature review

Michele Bisceglia, Francesco Perri, Antonio Tucci, Matteo Tardio, Gaetano Panniello, Giulia Vita, Gianandrea Pasquinelli

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Primary malignant melanoma originating in the digestive tract is particularly rare, mainly affecting the anorectum and oral cavity. Primary malignant melanoma of the esophagus has been the subject mostly of case reports. This tumor has a dismal prognosis with a frequency estimated to be approximately 0.1% to 0.2% of all esophageal malignancies. According to the review by Volpin et al of November 2002, 238 cases of primary malignant melanoma of the esophagus have been published up to early 2001. We present an additional case of primary malignant melanoma of the esophagus of the amelanotic variant in a 69-year-old man. The patient was preoperatively investigated by esophageal endoscopy and endoscopic ultrasound. The surgically resected tumor specimen was examined histologically and supplemented by immunohistochemical and ultrastructural analysis. Intra-abdominal relapse occurred after 8 months at the site of surgery, necessitating repeat resection. The patient died of advanced intra-abdominal disease 14 months after the primary diagnosis. A comprehensive computerized (PubMed/Medline) review of the world literature was also carried out and 99 additional cases (after the review by Volpin et al) were found, 9 of them from the 1990s which escaped previous tabulations, and 90 from the years 2000 to 2010, amounting to a grand total of 337 ever published.

Original languageEnglish
Pages (from-to)235-252
Number of pages18
JournalAdvances in Anatomic Pathology
Volume18
Issue number3
DOIs
Publication statusPublished - May 2011

Fingerprint

Esophagus
Melanoma
Neoplasms
Reoperation
PubMed
Endoscopy
Mouth
Gastrointestinal Tract
Recurrence

Keywords

  • electronmicroscopy
  • esophagus
  • immunohistochemistry
  • melanoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

Primary malignant melanoma of the esophagus : A clinicopathologic study of a case with comprehensive literature review. / Bisceglia, Michele; Perri, Francesco; Tucci, Antonio; Tardio, Matteo; Panniello, Gaetano; Vita, Giulia; Pasquinelli, Gianandrea.

In: Advances in Anatomic Pathology, Vol. 18, No. 3, 05.2011, p. 235-252.

Research output: Contribution to journalArticle

Bisceglia, Michele ; Perri, Francesco ; Tucci, Antonio ; Tardio, Matteo ; Panniello, Gaetano ; Vita, Giulia ; Pasquinelli, Gianandrea. / Primary malignant melanoma of the esophagus : A clinicopathologic study of a case with comprehensive literature review. In: Advances in Anatomic Pathology. 2011 ; Vol. 18, No. 3. pp. 235-252.
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