Abstract
A 55-year-old male presented with a 1-month history of localized pain caused by an osteolytic and destructive lesion in the right distal femur. Histologically, the tumour consisted of spindle cells intermingled with epithelioid eosinophilic cells arranged in small cords embedded in a hyalinized-to-chondromyxoid stroma. Electron microscopy and immunohistochemistry showed features of myoepithelial differentiation. RT-PCR failed to demonstrate chimeric transcripts of extraskeletal myxoid chondrosarcoma. The final diagnosis was primary malignant myoepithelioma of bone. The patient is alive with lung metastases 13 months after surgery. Primary malignant myoepithelioma of bone is an exceptionally rare neoplasm that should be considered in the differential diagnosis with the more aggressive myxoid spindle cell sarcomas.
| Original language | English |
|---|---|
| Pages (from-to) | 376-380 |
| Number of pages | 5 |
| Journal | APMIS |
| Volume | 115 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2007 |
Fingerprint
Keywords
- Malignant mixed tumours
- Malignant myoepitheliomas
- Malignant myxoid tumours
- Primary bone tumours
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Microbiology (medical)
- Immunology
Cite this
Primary malignant myoepithelioma of the distal femur : Case report. / Alberghini, M.; Pasquinelli, G.; Zanella, L.; Pignatti, G.; Benini, S.; Bacchini, P.; Bertoni, F.
In: APMIS, Vol. 115, No. 4, 04.2007, p. 376-380.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary malignant myoepithelioma of the distal femur
T2 - Case report
AU - Alberghini, M.
AU - Pasquinelli, G.
AU - Zanella, L.
AU - Pignatti, G.
AU - Benini, S.
AU - Bacchini, P.
AU - Bertoni, F.
PY - 2007/4
Y1 - 2007/4
N2 - A 55-year-old male presented with a 1-month history of localized pain caused by an osteolytic and destructive lesion in the right distal femur. Histologically, the tumour consisted of spindle cells intermingled with epithelioid eosinophilic cells arranged in small cords embedded in a hyalinized-to-chondromyxoid stroma. Electron microscopy and immunohistochemistry showed features of myoepithelial differentiation. RT-PCR failed to demonstrate chimeric transcripts of extraskeletal myxoid chondrosarcoma. The final diagnosis was primary malignant myoepithelioma of bone. The patient is alive with lung metastases 13 months after surgery. Primary malignant myoepithelioma of bone is an exceptionally rare neoplasm that should be considered in the differential diagnosis with the more aggressive myxoid spindle cell sarcomas.
AB - A 55-year-old male presented with a 1-month history of localized pain caused by an osteolytic and destructive lesion in the right distal femur. Histologically, the tumour consisted of spindle cells intermingled with epithelioid eosinophilic cells arranged in small cords embedded in a hyalinized-to-chondromyxoid stroma. Electron microscopy and immunohistochemistry showed features of myoepithelial differentiation. RT-PCR failed to demonstrate chimeric transcripts of extraskeletal myxoid chondrosarcoma. The final diagnosis was primary malignant myoepithelioma of bone. The patient is alive with lung metastases 13 months after surgery. Primary malignant myoepithelioma of bone is an exceptionally rare neoplasm that should be considered in the differential diagnosis with the more aggressive myxoid spindle cell sarcomas.
KW - Malignant mixed tumours
KW - Malignant myoepitheliomas
KW - Malignant myxoid tumours
KW - Primary bone tumours
UR - http://www.scopus.com/inward/record.url?scp=34248404069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248404069&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0463.2007.apm_569.x
DO - 10.1111/j.1600-0463.2007.apm_569.x
M3 - Article
VL - 115
SP - 376
EP - 380
JO - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section B Microbiology
JF - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section B Microbiology
SN - 0365-5555
IS - 4
ER -