Primary mediastinal B-cell lymphoma with sclerosis: Report of 11 cases treated with intensified-CHOP plus radiotherapy

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Abstract

Primary mediastinal B-cell lymphoma (PMBCL) is a clinicopathological entity with aggressive behavior. Retrospective evaluation suggests the need for intensive chemotherapy programs. From 1997 to February 2003, a total of 11 cases of previously untreated PMBCL with sclerosis were treated at our institution with 5 courses of intensified CHOP (ICHOP) regimen and mediastinal irradiation. Three patients were submitted to high-dose chemotherapy with peripheral-blood stem-cell support, followed by radiotherapy, because of intermediate-risk age-adjusted international Prognostic Index at diagnosis. After a median follow up of 30 months, all patients but one are in continuous complete remission (CR), and overall survival is 100%.

Original languageEnglish
Pages (from-to)312-313
Number of pages2
JournalAmerican Journal of Hematology
Volume78
Issue number4
DOIs
Publication statusPublished - Apr 2005

Keywords

  • B-cell lymphoma
  • ICHOP
  • Primary mediastinal lymphoma
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology

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