Primary mediastinal large B-cell lymphoma: Outcome of a series of pediatric patients treated with high-dose methotrexate and cytarabine plus anti-CD20

Marta Pillon, E. Carraro, L. Mussolin, V. Conter, A. Tondo, M. Aricò, R. Mura, A. Sala, L. Vinti, S. Buffardi, P. Pierani, E. S.G. d'Amore, G. Basso

Research output: Contribution to journalArticle

Abstract

Between 2007 and 2013, 13 children diagnosed with primary mediastinal large B-cell lymphoma (PMLBL) were treated according to a modified version of AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) LNH-97 protocol based on high-dose methotrexate, anthracyclines, and addition of anti-CD20. Ten patients achieved a continuous complete remission with front-line therapy. The overall 5-year survival was 91.7%, and event-free survival was 83.9%, with only one patient dying of progressive disease. Despite the few cases, these results demonstrate that this therapy, which includes anti-CD20, given in a multicenter setting, is feasible with acceptable toxicity in children with PMLBL.

Original languageEnglish
Article numbere26855
JournalPediatric Blood and Cancer
Volume65
Issue number2
DOIs
Publication statusPublished - Oct 19 2017

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Cytarabine
B-Cell Lymphoma
Methotrexate
Pediatrics
Anthracyclines
Disease-Free Survival
Survival
Therapeutics

Keywords

  • AIEOP LNH-97
  • childhood
  • NHL
  • PMLBL

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Primary mediastinal large B-cell lymphoma : Outcome of a series of pediatric patients treated with high-dose methotrexate and cytarabine plus anti-CD20. / Pillon, Marta; Carraro, E.; Mussolin, L.; Conter, V.; Tondo, A.; Aricò, M.; Mura, R.; Sala, A.; Vinti, L.; Buffardi, S.; Pierani, P.; d'Amore, E. S.G.; Basso, G.

In: Pediatric Blood and Cancer, Vol. 65, No. 2, e26855, 19.10.2017.

Research output: Contribution to journalArticle

Pillon, Marta ; Carraro, E. ; Mussolin, L. ; Conter, V. ; Tondo, A. ; Aricò, M. ; Mura, R. ; Sala, A. ; Vinti, L. ; Buffardi, S. ; Pierani, P. ; d'Amore, E. S.G. ; Basso, G. / Primary mediastinal large B-cell lymphoma : Outcome of a series of pediatric patients treated with high-dose methotrexate and cytarabine plus anti-CD20. In: Pediatric Blood and Cancer. 2017 ; Vol. 65, No. 2.
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AU - Conter, V.

AU - Tondo, A.

AU - Aricò, M.

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AU - Buffardi, S.

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