Primary monotypic epithelioid angiomyolipoma of bone

L. Insabato; G. De Rosa; L. M. Terracciano; F. Fazioli; F. Di Santo; J. Rosai

doi:10.1046/j.1365-2559.2002.01356.x

Primary monotypic epithelioid angiomyolipoma of bone

L. Insabato, G. De Rosa, L. M. Terracciano, F. Fazioli, F. Di Santo, J. Rosai

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: Monotypic epithelioid angiomyolipoma is a distinct and definable variant of angiomyolipoma, composed of monomorphous epithelioid cells that show HMB45 immunoreactivity. Angiomyolipoma, including its morphological variants, belongs to the family of perivascular epithelioid cell tumour. Methods and results: The tumour was examined using immunohistochemical staining and by transmission electron microscopy. Neoplastic cells showed a cytoplasmic granular positivity for HMB45. Conclusions: Extrarenal angiomyolipomas are rare and, to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid angiomyolipoma of bone in a patient without evidence of tuberous sclerosis.

Original language	English
Pages (from-to)	286-290
Number of pages	5
Journal	Histopathology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2559.2002.01356.x
Publication status	Published - 2002

Keywords

Bone
Epithelioid angiomyolipoma
Monotypic

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine
Cell Biology

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10.1046/j.1365-2559.2002.01356.x

Cite this

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title = "Primary monotypic epithelioid angiomyolipoma of bone",

abstract = "Aims: Monotypic epithelioid angiomyolipoma is a distinct and definable variant of angiomyolipoma, composed of monomorphous epithelioid cells that show HMB45 immunoreactivity. Angiomyolipoma, including its morphological variants, belongs to the family of perivascular epithelioid cell tumour. Methods and results: The tumour was examined using immunohistochemical staining and by transmission electron microscopy. Neoplastic cells showed a cytoplasmic granular positivity for HMB45. Conclusions: Extrarenal angiomyolipomas are rare and, to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid angiomyolipoma of bone in a patient without evidence of tuberous sclerosis.",

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T1 - Primary monotypic epithelioid angiomyolipoma of bone

AU - Insabato, L.

AU - De Rosa, G.

AU - Terracciano, L. M.

AU - Fazioli, F.

AU - Di Santo, F.

AU - Rosai, J.

PY - 2002

Y1 - 2002

N2 - Aims: Monotypic epithelioid angiomyolipoma is a distinct and definable variant of angiomyolipoma, composed of monomorphous epithelioid cells that show HMB45 immunoreactivity. Angiomyolipoma, including its morphological variants, belongs to the family of perivascular epithelioid cell tumour. Methods and results: The tumour was examined using immunohistochemical staining and by transmission electron microscopy. Neoplastic cells showed a cytoplasmic granular positivity for HMB45. Conclusions: Extrarenal angiomyolipomas are rare and, to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid angiomyolipoma of bone in a patient without evidence of tuberous sclerosis.

AB - Aims: Monotypic epithelioid angiomyolipoma is a distinct and definable variant of angiomyolipoma, composed of monomorphous epithelioid cells that show HMB45 immunoreactivity. Angiomyolipoma, including its morphological variants, belongs to the family of perivascular epithelioid cell tumour. Methods and results: The tumour was examined using immunohistochemical staining and by transmission electron microscopy. Neoplastic cells showed a cytoplasmic granular positivity for HMB45. Conclusions: Extrarenal angiomyolipomas are rare and, to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid angiomyolipoma of bone in a patient without evidence of tuberous sclerosis.

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KW - Epithelioid angiomyolipoma

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Primary monotypic epithelioid angiomyolipoma of bone

Abstract

Keywords

ASJC Scopus subject areas

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