Primary multifocal lymphoma of peripheral nervous system: Case report and review of the literature

Alessandra Del Grande, Mario Sabatelli, Marco Luigetti, Amelia Conte, Giuseppe Granata, Vittoria Rufini, Annemilia Del Ciello, Simona Gaudino, Eduardo Fernandez, Stefan Hohaus, Antonella Coli, Libero Lauriola

Research output: Contribution to journalArticlepeer-review


Introduction: Primary lymphomas of peripheral nerves are extremely rare, and only a few cases have been reported. Methods: We describe the clinical, neurophysiological, radiological, and pathological findings in a 61-year-old woman affected by primary multifocal lymphoma of the peripheral nervous system without systemic involvement. Results: Fascicular left femoral nerve biopsy was decisive for the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Magnetic resonance imaging, fluorine-18 fluorodeoxyglucose positron emission tomography computed tomography, and nerve ultrasound contributed to the diagnosis. Conclusions: Primary lymphoma of peripheral nerves (PLPNs) is a rare but potentially treatable condition, which is frequently misdiagnosed. In the literature, there are very few descriptions of PLPNs, most of which are mononeuropathies. The possibility of a neuropathy associated with lymphoma should be considered in patients with poor response to treatment and severe pain symptoms.

Original languageEnglish
Pages (from-to)1016-1022
Number of pages7
JournalMuscle and Nerve
Issue number6
Publication statusPublished - Dec 1 2014


  • Nerve biopsy
  • Nerve ultrasound
  • Neurolymphomatosis
  • Primary lymphoma of peripheral nerves

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology
  • Medicine(all)


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