Primary neuroendocrine tumours of the thymus

a clinicopathologic and prognostic study in 19 patients

Giuseppe Cardillo, Stefano Treggiari, Marinus A. Paul, Francesco Carleo, Alessia Raffaella De Massimi, Daniele Remotti, Paolo Graziano, Massimo Martelli

Research output: Contribution to journalArticle

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Abstract

Background: We sought to evaluate factors influencing long-term survival in 19 patients with primary neuroendocrine tumours of the thymus. Methods: From January 1990 to December 2004, 19 patients (14 males, 5 females; mean age 48.6 years) were surgically treated for a primary neuroendocrine tumour of the thymus. Results: All patients underwent radical R0 thymomectomy and were followed up for a total of 1459 months (median: 69 months; range: 8-180). Nine patients had associated paraneoplastic syndrome. No operative mortality occurred. Two patients underwent re-do surgery because of local recurrence, respectively, 25 and 35 months after surgery. Five patients died of disease, respectively, 51, 70, 95, 131 and 153 months after surgery. One patient died of myocardial infarction with no evidence of disease. Thirteen patients are alive, of which 10 are free from disease and three with disease. The overall 5-year and 10-year actuarial survival rates were 91.6% and 69.8%, respectively (median survival: 153 months). The 10-year survival was evaluated according to histology (typical carcinoid 100%; atypical carcinoid: 66.6%; large cell neuroendocrine tumours: 0%), Masaoka staging (stage I: 100%; stage II: 50%; stage III: 66.6%; stage IV: 0%), presence of paraneoplastic syndrome (no: 87.5%; yes: 0%) and postoperative radiotherapy (yes: 40%; no: 83.3%). Conclusions: The prognosis of primary neuroendocrine tumours of the thymus is related to the grading of the neoplasm, the presence of a paraneoplastic syndrome and to the Masaoka staging but not to the postoperative radiotherapy.

Original languageEnglish
Pages (from-to)814-818
Number of pages5
JournalEuropean Journal of Cardio-thoracic Surgery
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Neuroendocrine Tumors
Thymus Gland
Paraneoplastic Syndromes
Carcinoid Tumor
Survival
Radiotherapy
Neoplasm Grading
Histology
Survival Rate
Myocardial Infarction
Recurrence
Mortality

Keywords

  • Carcinoid
  • Surgery
  • Thymus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Cardillo, G., Treggiari, S., Paul, M. A., Carleo, F., De Massimi, A. R., Remotti, D., ... Martelli, M. (2010). Primary neuroendocrine tumours of the thymus: a clinicopathologic and prognostic study in 19 patients. European Journal of Cardio-thoracic Surgery, 37(4), 814-818. https://doi.org/10.1016/j.ejcts.2009.10.026

Primary neuroendocrine tumours of the thymus : a clinicopathologic and prognostic study in 19 patients. / Cardillo, Giuseppe; Treggiari, Stefano; Paul, Marinus A.; Carleo, Francesco; De Massimi, Alessia Raffaella; Remotti, Daniele; Graziano, Paolo; Martelli, Massimo.

In: European Journal of Cardio-thoracic Surgery, Vol. 37, No. 4, 04.2010, p. 814-818.

Research output: Contribution to journalArticle

Cardillo, Giuseppe ; Treggiari, Stefano ; Paul, Marinus A. ; Carleo, Francesco ; De Massimi, Alessia Raffaella ; Remotti, Daniele ; Graziano, Paolo ; Martelli, Massimo. / Primary neuroendocrine tumours of the thymus : a clinicopathologic and prognostic study in 19 patients. In: European Journal of Cardio-thoracic Surgery. 2010 ; Vol. 37, No. 4. pp. 814-818.
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AU - Carleo, Francesco

AU - De Massimi, Alessia Raffaella

AU - Remotti, Daniele

AU - Graziano, Paolo

AU - Martelli, Massimo

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AB - Background: We sought to evaluate factors influencing long-term survival in 19 patients with primary neuroendocrine tumours of the thymus. Methods: From January 1990 to December 2004, 19 patients (14 males, 5 females; mean age 48.6 years) were surgically treated for a primary neuroendocrine tumour of the thymus. Results: All patients underwent radical R0 thymomectomy and were followed up for a total of 1459 months (median: 69 months; range: 8-180). Nine patients had associated paraneoplastic syndrome. No operative mortality occurred. Two patients underwent re-do surgery because of local recurrence, respectively, 25 and 35 months after surgery. Five patients died of disease, respectively, 51, 70, 95, 131 and 153 months after surgery. One patient died of myocardial infarction with no evidence of disease. Thirteen patients are alive, of which 10 are free from disease and three with disease. The overall 5-year and 10-year actuarial survival rates were 91.6% and 69.8%, respectively (median survival: 153 months). The 10-year survival was evaluated according to histology (typical carcinoid 100%; atypical carcinoid: 66.6%; large cell neuroendocrine tumours: 0%), Masaoka staging (stage I: 100%; stage II: 50%; stage III: 66.6%; stage IV: 0%), presence of paraneoplastic syndrome (no: 87.5%; yes: 0%) and postoperative radiotherapy (yes: 40%; no: 83.3%). Conclusions: The prognosis of primary neuroendocrine tumours of the thymus is related to the grading of the neoplasm, the presence of a paraneoplastic syndrome and to the Masaoka staging but not to the postoperative radiotherapy.

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