Primary nodal marginal zone B-cell lymphoma: Clinical features and prognostic assessment of a rare disease

Luca Arcaini, Marco Paulli, Sara Burcheri, Andrea Rossi, Michele Spina, Francesco Passamonti, Marco Lucioni, Teresio Motta, Vincenzo Canzonieri, Mauro Montanari, Emanuela Bonoldi, Andrea Gallamini, Lilj Uziel, Monica Crugnola, Antonio Ramponi, Francesca Montanari, Cristiana Pascutto, Enrica Morra, Mario Lazzarino

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalBritish Journal of Haematology
Volume136
Issue number2
DOIs
Publication statusPublished - Jan 2007

Fingerprint

Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
Rare Diseases
Survival
Serology
L-Lactate Dehydrogenase
Hepacivirus
Multivariate Analysis

Keywords

  • Hepatitis C virus
  • Low-grade non-Hodgkin lymphoma
  • Marginal zone
  • Nodal marginal zone lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Primary nodal marginal zone B-cell lymphoma : Clinical features and prognostic assessment of a rare disease. / Arcaini, Luca; Paulli, Marco; Burcheri, Sara; Rossi, Andrea; Spina, Michele; Passamonti, Francesco; Lucioni, Marco; Motta, Teresio; Canzonieri, Vincenzo; Montanari, Mauro; Bonoldi, Emanuela; Gallamini, Andrea; Uziel, Lilj; Crugnola, Monica; Ramponi, Antonio; Montanari, Francesca; Pascutto, Cristiana; Morra, Enrica; Lazzarino, Mario.

In: British Journal of Haematology, Vol. 136, No. 2, 01.2007, p. 301-304.

Research output: Contribution to journalArticle

Arcaini, L, Paulli, M, Burcheri, S, Rossi, A, Spina, M, Passamonti, F, Lucioni, M, Motta, T, Canzonieri, V, Montanari, M, Bonoldi, E, Gallamini, A, Uziel, L, Crugnola, M, Ramponi, A, Montanari, F, Pascutto, C, Morra, E & Lazzarino, M 2007, 'Primary nodal marginal zone B-cell lymphoma: Clinical features and prognostic assessment of a rare disease', British Journal of Haematology, vol. 136, no. 2, pp. 301-304. https://doi.org/10.1111/j.1365-2141.2006.06437.x
Arcaini, Luca ; Paulli, Marco ; Burcheri, Sara ; Rossi, Andrea ; Spina, Michele ; Passamonti, Francesco ; Lucioni, Marco ; Motta, Teresio ; Canzonieri, Vincenzo ; Montanari, Mauro ; Bonoldi, Emanuela ; Gallamini, Andrea ; Uziel, Lilj ; Crugnola, Monica ; Ramponi, Antonio ; Montanari, Francesca ; Pascutto, Cristiana ; Morra, Enrica ; Lazzarino, Mario. / Primary nodal marginal zone B-cell lymphoma : Clinical features and prognostic assessment of a rare disease. In: British Journal of Haematology. 2007 ; Vol. 136, No. 2. pp. 301-304.
@article{ba88209d6f3042b59d27e0ee93352eb6,
title = "Primary nodal marginal zone B-cell lymphoma: Clinical features and prognostic assessment of a rare disease",
abstract = "This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24{\%}. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33{\%} were classified as low-risk, 34{\%} as intermediate-risk, and 33{\%} as high-risk. The 5-year overall survival (OS) was 69{\%}. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).",
keywords = "Hepatitis C virus, Low-grade non-Hodgkin lymphoma, Marginal zone, Nodal marginal zone lymphoma, Prognosis",
author = "Luca Arcaini and Marco Paulli and Sara Burcheri and Andrea Rossi and Michele Spina and Francesco Passamonti and Marco Lucioni and Teresio Motta and Vincenzo Canzonieri and Mauro Montanari and Emanuela Bonoldi and Andrea Gallamini and Lilj Uziel and Monica Crugnola and Antonio Ramponi and Francesca Montanari and Cristiana Pascutto and Enrica Morra and Mario Lazzarino",
year = "2007",
month = "1",
doi = "10.1111/j.1365-2141.2006.06437.x",
language = "English",
volume = "136",
pages = "301--304",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "2",

}

TY - JOUR

T1 - Primary nodal marginal zone B-cell lymphoma

T2 - Clinical features and prognostic assessment of a rare disease

AU - Arcaini, Luca

AU - Paulli, Marco

AU - Burcheri, Sara

AU - Rossi, Andrea

AU - Spina, Michele

AU - Passamonti, Francesco

AU - Lucioni, Marco

AU - Motta, Teresio

AU - Canzonieri, Vincenzo

AU - Montanari, Mauro

AU - Bonoldi, Emanuela

AU - Gallamini, Andrea

AU - Uziel, Lilj

AU - Crugnola, Monica

AU - Ramponi, Antonio

AU - Montanari, Francesca

AU - Pascutto, Cristiana

AU - Morra, Enrica

AU - Lazzarino, Mario

PY - 2007/1

Y1 - 2007/1

N2 - This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).

AB - This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).

KW - Hepatitis C virus

KW - Low-grade non-Hodgkin lymphoma

KW - Marginal zone

KW - Nodal marginal zone lymphoma

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=33845894185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845894185&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2006.06437.x

DO - 10.1111/j.1365-2141.2006.06437.x

M3 - Article

C2 - 17233821

AN - SCOPUS:33845894185

VL - 136

SP - 301

EP - 304

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -