Primary nodal marginal zone B-cell lymphoma: Clinical features and prognostic assessment of a rare disease

Luca Arcaini, Marco Paulli, Sara Burcheri, Andrea Rossi, Michele Spina, Francesco Passamonti, Marco Lucioni, Teresio Motta, Vincenzo Canzonieri, Mauro Montanari, Emanuela Bonoldi, Andrea Gallamini, Lilj Uziel, Monica Crugnola, Antonio Ramponi, Francesca Montanari, Cristiana Pascutto, Enrica Morra, Mario Lazzarino

Research output: Contribution to journalArticle

Abstract

This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalBritish Journal of Haematology
Volume136
Issue number2
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Hepatitis C virus
  • Low-grade non-Hodgkin lymphoma
  • Marginal zone
  • Nodal marginal zone lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Hematology

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    Arcaini, L., Paulli, M., Burcheri, S., Rossi, A., Spina, M., Passamonti, F., Lucioni, M., Motta, T., Canzonieri, V., Montanari, M., Bonoldi, E., Gallamini, A., Uziel, L., Crugnola, M., Ramponi, A., Montanari, F., Pascutto, C., Morra, E., & Lazzarino, M. (2007). Primary nodal marginal zone B-cell lymphoma: Clinical features and prognostic assessment of a rare disease. British Journal of Haematology, 136(2), 301-304. https://doi.org/10.1111/j.1365-2141.2006.06437.x