Abstract
Primary oxalosis type I is due to an abnormal metabolism of glyoxylate at the hepatic level responsible of hyperoxaluria. In affected patients, a deposition of calcium oxalate crystals occurs throughout body tissues and the excessive urinary excretion of oxalic acid is the cause of renal and urinary tract lithiasis and nephrocalcinosis leading to renal insufficiency. As soon as the diagnostic has been established (by estimation of blood and urinary levels of oxalate, urinary metabolites and the enzyme activity on a liver biopsy), a medical treatment has to be started. The renal function has to be followed accurately as well as oxalate levels in blood and urine. In the resistant forms of the disease, liver transplantation is the only way to correct the metabolic defect. Renal transplantation may or has to be done at the same time if the renal function is impaired to improve the renal function and to accelerate the removal of oxalate.
| Original language | French |
|---|---|
| Pages (from-to) | 640-651 |
| Number of pages | 12 |
| Journal | Louvain Medical |
| Volume | 113 |
| Issue number | 9 |
| Publication status | Published - 1994 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
L'OXALOSE PRIMAIRE DE TYPE I. MISE AU POINT ET STRATEGIE THERAPEUTIQUE ACTUELLE. / Jacques, I.; De Ville De Goyet, J.; Wese, F. X.; Otte, J. B.; Cornu, G.
In: Louvain Medical, Vol. 113, No. 9, 1994, p. 640-651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - L'OXALOSE PRIMAIRE DE TYPE I. MISE AU POINT ET STRATEGIE THERAPEUTIQUE ACTUELLE
AU - Jacques, I.
AU - De Ville De Goyet, J.
AU - Wese, F. X.
AU - Otte, J. B.
AU - Cornu, G.
PY - 1994
Y1 - 1994
N2 - Primary oxalosis type I is due to an abnormal metabolism of glyoxylate at the hepatic level responsible of hyperoxaluria. In affected patients, a deposition of calcium oxalate crystals occurs throughout body tissues and the excessive urinary excretion of oxalic acid is the cause of renal and urinary tract lithiasis and nephrocalcinosis leading to renal insufficiency. As soon as the diagnostic has been established (by estimation of blood and urinary levels of oxalate, urinary metabolites and the enzyme activity on a liver biopsy), a medical treatment has to be started. The renal function has to be followed accurately as well as oxalate levels in blood and urine. In the resistant forms of the disease, liver transplantation is the only way to correct the metabolic defect. Renal transplantation may or has to be done at the same time if the renal function is impaired to improve the renal function and to accelerate the removal of oxalate.
AB - Primary oxalosis type I is due to an abnormal metabolism of glyoxylate at the hepatic level responsible of hyperoxaluria. In affected patients, a deposition of calcium oxalate crystals occurs throughout body tissues and the excessive urinary excretion of oxalic acid is the cause of renal and urinary tract lithiasis and nephrocalcinosis leading to renal insufficiency. As soon as the diagnostic has been established (by estimation of blood and urinary levels of oxalate, urinary metabolites and the enzyme activity on a liver biopsy), a medical treatment has to be started. The renal function has to be followed accurately as well as oxalate levels in blood and urine. In the resistant forms of the disease, liver transplantation is the only way to correct the metabolic defect. Renal transplantation may or has to be done at the same time if the renal function is impaired to improve the renal function and to accelerate the removal of oxalate.
UR - http://www.scopus.com/inward/record.url?scp=0027944704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027944704&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0027944704
VL - 113
SP - 640
EP - 651
JO - Revue medicale de Louvain
JF - Revue medicale de Louvain
SN - 0024-6956
IS - 9
ER -