Artrite reumatoide: Ruolo chiave dell'interleuchina-6 nel network citochinico infiammatorio

Translated title of the contribution: Primary pathologic role of interleukin-6 in rheumatoid arthritis

Gianluigi L. Bajocchi, N. Pipitone, P. L. Boiardi, C. Salvarani

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Interleukin-6 (IL-6) is a polyfunctional cytokine that regulates a very large number of cellular activities. Its implication in acute-phase reactant production by hepatocytes is of particular interest, as is its involvement in chronic inflammatory diseases, mainly rheumatoid arthritis, Crohn's disease, and Castleman's disease. Transgenic mice lacking IL-6 expression were completely protected against collagen-induced arthritis, and Tumor Necrosis Factor (TNF-alpha) induces synovial cells to produce IL-6 and their proliferation. However, there is still some controversies regarding the unique proinflammatory activity of IL-6. Some studies have demonstrated that IL-6 and TNF-alpha may have an opposite effect in synovial cultured cells since IL-6 could represent a negative loop for TNF-alpha induced synovitis. However, phase III studies of rheumatoid arthritis patients treated with anti IL-6 receptor (tocilizumab) indicate an acceptable safety profile relative to the clinical benefit. AIM OF THE STUDY: In this review, we summarized the rationale and the main evidence regarding the therapeutic benefit of blocking IL-6 activity in rheumatoid arthritis.

Translated title of the contributionPrimary pathologic role of interleukin-6 in rheumatoid arthritis
Original languageItalian
Pages (from-to)40-46
Number of pages7
JournalItalian Journal of Medicine
Volume2
Issue number4
Publication statusPublished - Dec 2008

ASJC Scopus subject areas

  • Medicine(all)

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    Bajocchi, G. L., Pipitone, N., Boiardi, P. L., & Salvarani, C. (2008). Artrite reumatoide: Ruolo chiave dell'interleuchina-6 nel network citochinico infiammatorio. Italian Journal of Medicine, 2(4), 40-46.