Primary peritoneal cancer in lynch syndrome: A clinical-pathologic report of a case and analysis of the literature

Fabio Ghezzi, Stefano Uccella, Antonella Cromi, Giorgio Bogani, Nicoletta Donadello, Cristina Riva

Research output: Contribution to journalArticle

Abstract

Lynch syndrome is a genetic disease, caused by a germ-line mutation in a mismatch repair gene, related to an increased risk of developing colorectal and extracolonic cancer. Despite that, the incidence of primary peritoneal cancer after adnexectomy remains unknown. We here report a case of primary peritoneal cancer in a woman affected by Lynch syndrome who underwent hysterectomy+salpingo-oophorectomy for endometrial cancer 13 yr before. Morphology and immunophenotype allowed to differentiate peritoneal malignancy from the previously diagnosed endometrial carcinoma. Physicians should be aware of the potential risk of primary peritoneal cancer in women affected by Lynch syndrome, despite previous prophylactic surgery.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalInternational Journal of Gynecological Pathology
Volume32
Issue number2
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Endometrial cancer
  • HNPCC
  • Lynch syndrome
  • Primary peritoneal cancer
  • Prophylactic surgery

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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