Primary progressive multiple sclerosis

A. J. Thompson, C. H. Polman, D. H. Miller, W. I. McDonald, B. Brochet, M. Filippi, X. Montalban, J. De Sá

Research output: Contribution to journalArticlepeer-review


Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration The prognosis is poor and there are currently no treatment trials for this form of the disease.

Original languageEnglish
Pages (from-to)1085-1096
Number of pages12
Issue number6
Publication statusPublished - Jun 1997


  • Diagnosis
  • Multiple sclerosis
  • Primary progressive

ASJC Scopus subject areas

  • Neuroscience(all)


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