Primary prophylaxis of variceal bleeding in cirrhotic patients: A cohort study

A. Dell'Era, J. Cubero Sotela, F. M. Fabris, G. Petazzi, R. Reati, F. Iannuzzi, A. Nicolini, M. G. Rumi, R. de Franchis, M. Primignani

Research output: Contribution to journalArticlepeer-review


Background: Current guidelines recommend beta-blockers for primary prevention of variceal haemorrhage in cirrhotic patients, and band ligation for patients with contraindications or intolerance to beta-blockers. However, it has been suggested that these patients may respond poorly to band ligation. Aim: We evaluated the usefulness of a strategy in which band ligation was used to treat patients with contraindications or intolerance and patients not responding to beta-blockers identified by hepatic vein pressure gradient measurement. Haemodynamic responders and patients refusing hepatic vein pressure gradient measurement were given long-term beta-blockers. Methods: One hundred and thirty-five consecutive patients with high-risk oesophageal varices and no prior bleeding were enrolled. Twenty-five patients with contraindications (group A), 26 with intolerance to beta-blockers (group B) and 25 showing a poor haemodynamic response (Group C) underwent band ligation. Twenty-two haemodynamic responders (Group D) and 37 refusing hepatic vein pressure gradient measurement (Group E) were treated with beta-blockers. Results: Median follow-up was 32 months. 12/135 patients (8.9%) bled: 3/25 (12%) in group A, 1/26 (3.8%) in group B, 0/25 (0%) in group C, 0/22 (0%) in group D and 8/37 (22.2%) in group E. Mortality was 8/135 (5.9%). Conclusions: Patients with contraindications, intolerance or not responding to beta-blockers treated with band ligation achieve protection from variceal bleeding comparable to that of good responders to beta-blockers.

Original languageEnglish
Pages (from-to)936-943
Number of pages8
JournalDigestive and Liver Disease
Issue number12
Publication statusPublished - Dec 2008


  • Beta-blockers
  • Endoscopic band ligation
  • Hepatic vein pressure gradient
  • Oesophageal varices

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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