Primary pulmonary hypertension in HIV patients: A systematic review

A. M. Pellicelli, G. Barbaro, F. Palmieri, E. Girardi, C. D'Ambrosio, A. Rianda, G. Barbarini, D. Frigiotti, M. C. Borgia, N. Petrosillo

Research output: Contribution to journalArticle

Abstract

The relationship between grade of pulmonary hypertension and factors associated with human immunodeficiency virus among patients with HIV infection is poorly documented. This report documents the most extensive attempt made thus far to determine whether a relationship exists between degree of pulmonary hypertension and the following conditions: HIV risk factor, degree of immunosuppression, presence or absence of AIDS, and presence or absence of liver cirrhosis. A retrospective study involving a search of the published literature on primary pulmonary hypertension among HIV cases from 1987 to 1998, using the Medline and Aidsline databases was conducted. Patients for whom secondary causes of pulmonary hypertension could be excluded were selected, and the following information for each was recorded: age, gender, risk factors for HIV infection, HIV disease stage according to the Centers for Disease Control, previous opportunistic and neoplastic diseases, CD4+ cell count (cells/L), presence or absence of liver cirrhosis, pulmonary systolic artery pressure level, and lung pathology specimens. Information about the patient's survival time was also recorded. Seventy-six patients were judged to have primary pulmonary hypertension and were included in the study. While no correlation was found between pulmonary systolic artery pressure level and CD4+ cell counts, a statistically significant difference was found between HIV-positive patients with and without AIDS as determined by the Centers for Disease Control criteria with regard to the degree of pulmonary hypertension, expressed as pulmonary systolic artery pressure level (85.4 ±17 mm Hg vs 71.8±15 mm Hg, p

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalAngiology
Volume52
Issue number1
Publication statusPublished - 2001

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Pulmonary Hypertension
HIV
Pulmonary Artery
Centers for Disease Control and Prevention (U.S.)
CD4 Lymphocyte Count
Blood Pressure
Liver Cirrhosis
HIV Infections
Acquired Immunodeficiency Syndrome
Immunosuppression
Retrospective Studies
Familial Primary Pulmonary Hypertension
Databases
Pathology
Lung
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Primary pulmonary hypertension in HIV patients : A systematic review. / Pellicelli, A. M.; Barbaro, G.; Palmieri, F.; Girardi, E.; D'Ambrosio, C.; Rianda, A.; Barbarini, G.; Frigiotti, D.; Borgia, M. C.; Petrosillo, N.

In: Angiology, Vol. 52, No. 1, 2001, p. 31-41.

Research output: Contribution to journalArticle

Pellicelli, AM, Barbaro, G, Palmieri, F, Girardi, E, D'Ambrosio, C, Rianda, A, Barbarini, G, Frigiotti, D, Borgia, MC & Petrosillo, N 2001, 'Primary pulmonary hypertension in HIV patients: A systematic review', Angiology, vol. 52, no. 1, pp. 31-41.
Pellicelli, A. M. ; Barbaro, G. ; Palmieri, F. ; Girardi, E. ; D'Ambrosio, C. ; Rianda, A. ; Barbarini, G. ; Frigiotti, D. ; Borgia, M. C. ; Petrosillo, N. / Primary pulmonary hypertension in HIV patients : A systematic review. In: Angiology. 2001 ; Vol. 52, No. 1. pp. 31-41.
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