Leiomioma primitivo del polmone, con aspetti a cellule chiare e con spazi alveolari frammisti: Descrizione di un caso presentatosi con pneumotorace

Translated title of the contribution: Primary pulmonary leiomyoma, with clear cell features and with admixed epithelial spaces: Report of a case presenting with pneumothorax

Alberto Cavazza, G. Rossi, M. Paci, V. Annessi, G. Ferrari, S. Pellegrino, L. De Marco

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To report about a primary leiomyoma of the lung, with clear cell features and with admixed alveolar epithelium. Results and conclusions: The patients, a 18-year-old female, non smoker presented with a well-delimited pleuro-pulmonary mass, 6,5 cm across, located in the right upper lobe. The mass was discovered 5 years previously, following an episode of spontaneous pneumothorax; initially interpreted as an intralobar pulmonary sequestration, it was subsequently removed due to a small dimensional increase. A gynaecological examination, a thoracic CT-scan obtained 2 years after operation, and a recent adbomino-pelvic echography were negative. The patient is alive and well 7 years after surgery. Microscopically, the lesion was well delimited and it was punctuated by multiple cysts of variable dimensions, covered by bland cubic cells. The solid part of the lesion was composed by oval, clear cells, merging with fusiform elements with densely eosinophilic cytoplasm. Significant atypia, mitoses and necrosis were absent. Immunohistochemically, both oval and spindle cells were strongly positive for vimentin, smooth muscle actin, desmin and h-caldesmon, negative for cytokeratin, EMA, CD-34, CD-10, CD-117, HMB-45, TTF-1, BCL-2, GFAP, calretinin, chromogranin, estrogen and progesterone receptors. Cells covering the cystic spaces were positive for cytokeratin, TTF-1 and EMA, negative for all the other antibodies tested. Smooth muscle proliferations of the lung are briefly discussed, together with the most important problems in differential diagnosis.

Translated title of the contributionPrimary pulmonary leiomyoma, with clear cell features and with admixed epithelial spaces: Report of a case presenting with pneumothorax
Original languageItalian
Pages (from-to)108-114
Number of pages7
JournalPathologica
Volume95
Issue number2
Publication statusPublished - Apr 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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