Primary sellar melanocytoma: pathological, clinical and treatment review: Journal of Endocrinological Investigation

L. Albano, M. Losa, L.R. Barzaghi, G. Spatola, P. Panni, M.R. Terreni, P. Mortini

Research output: Contribution to journalArticlepeer-review


Background: Sellar melanocytomas represent a small subgroup of primary melanocytic tumors. They arise from melanocytes located in the meningeal lining of the sellar floor or in the diaphragma sellae and this location is very uncommon. Usually, sellar melanocytomas are benign and slow-growing tumors with a high likelihood of recurrence. Purpose: To our knowledge, due to the rarity of this condition, there are no guidelines regarding their diagnosis and treatment in the medical literature to date. We have developed a narrative review, analyzing the available studies regarding primary sellar melanocytomas reported in the medical literature. We have found ten papers on this topic and all of them are case reports. In all patients, tumor diagnosis was performed after the occurrence of neurological symptoms, in particular progressive visual loss or endocrinological disorders. The diagnosis is difficult, and it requires several preoperative and postoperative investigations, but histological examination is crucial. Conclusions: Transsphenoidal surgery is the first-choice treatment. In case of tumor’s recurrence or regrowth, the role of radiation therapy and chemotherapy is not entirely clear. © 2019, Italian Society of Endocrinology (SIE).
Original languageEnglish
Pages (from-to)575-585
Number of pages11
JournalJ. Endocrinol. Invest.
Issue number5
Publication statusPublished - 2020


  • Leptomeningeal melanocytes
  • Pituitary tumor
  • Primary melanocytic brain tumors
  • Sellar melanocytoma
  • Transsphenoidal surgery
  • dopamine receptor stimulating agent
  • levothyroxine
  • prolactin
  • steroid
  • adjuvant radiotherapy
  • clinical feature
  • computer assisted tomography
  • craniotomy
  • differential diagnosis
  • endocrine system metastasis
  • gamma knife radiosurgery
  • gene mutation
  • histopathology
  • human
  • hyperprolactinemia
  • hypophysis adenoma
  • melanocytosis
  • melanoma
  • molecular genetics
  • nuclear magnetic resonance imaging
  • pathogenesis
  • pituitary metastasis
  • primary sellar melanocytoma
  • prognosis
  • Review
  • sella turcica tumor
  • systematic review
  • transsphenoidal surgery
  • tumor recurrence
  • hypophysis
  • hypophysis tumor
  • melanocyte
  • pathology
  • Humans
  • Melanocytes
  • Pituitary Gland
  • Pituitary Neoplasms


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