Primary shunt hyperbilirubinemia associated with Gilbert's syndrome

E. Cofrancesco, M. Salvatore, M. P. Fenu, E. M. Pogliani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A patient with primary shunt hyperbilirubinemia associated with Gilbert's syndrome is described. The laboratory findings of unconjugated hyperbilirubinemia, mild reticulocytosis, normoblastic erythroid hyperplasia of bone marrow, increased plasma iron turnover, and normal peripheral red blood cell survival were consistent with increased intramedullary hemolysis. Nevertheless, unconjugated bilirubin level exceeding 4 mg/100 mL, in the absence of appreciable anemia and of biochemical evidence of hepatic dysfunction, suggested the coexistence of defective hepatic bilirubin clearance. The mode of inheritance and the effect of fasting and phenobarbital on bilirubin concentrations were indicative of associated Gilbert's syndrome.

Original languageEnglish
Pages (from-to)627-629
Number of pages3
JournalAmerican Journal of Clinical Pathology
Volume79
Issue number5
Publication statusPublished - 1983

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Gilbert Disease
Bilirubin
Reticulocytosis
Hyperbilirubinemia
Liver
Phenobarbital
Hemolysis
Hyperplasia
Anemia
Fasting
Cell Survival
Iron
Erythrocytes
Bone Marrow
Shunt Hyperbilirubinemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Primary shunt hyperbilirubinemia associated with Gilbert's syndrome. / Cofrancesco, E.; Salvatore, M.; Fenu, M. P.; Pogliani, E. M.

In: American Journal of Clinical Pathology, Vol. 79, No. 5, 1983, p. 627-629.

Research output: Contribution to journalArticle

Cofrancesco, E, Salvatore, M, Fenu, MP & Pogliani, EM 1983, 'Primary shunt hyperbilirubinemia associated with Gilbert's syndrome', American Journal of Clinical Pathology, vol. 79, no. 5, pp. 627-629.
Cofrancesco, E. ; Salvatore, M. ; Fenu, M. P. ; Pogliani, E. M. / Primary shunt hyperbilirubinemia associated with Gilbert's syndrome. In: American Journal of Clinical Pathology. 1983 ; Vol. 79, No. 5. pp. 627-629.
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