Primary somatosensory contribution to action observation brain activity-combining fMRI and cTBS

Nikola Valchev, Valeria Gazzola, Alessio Avenanti, Christian Keysers

Research output: Contribution to journalArticle

Abstract

Traditionally the mirror neuron system (MNS) only includes premotor and posterior parietal cortices. However, somatosensory cortices, BA1/2 in particular, are also activated during action execution and observation. Here, we examine whether BA1/2 and the parietofrontal MNS integrate information by using functional magnetic resonance imaging (fMRI)- guided continuous theta-burst stimulation (cTBS) to perturb BA1/2. Measuring brain activity using fMRI while participants are under the influence of cTBS shows local cTBS effects in BA1/2 varied, with some participants showing decreases and others increases in the BOLD response to viewing actions vs control stimuli. We show how measuring cTBS effects using fMRI can harness this variance using a whole-brain regression. This analysis identifies brain regions exchanging actionspecific information with BA1/2 by mapping voxels away from the coil with cTBS-induced, action-observation-specific BOLD contrast changes that mirror those under the coil. This reveals BA1/2 exchanges action-specific information with premotor, posterior parietal and temporal nodes of the MNS during action observation. Although anatomical connections between BA1/2 and these regions are well known, this is the first demonstration that these connections carry action-specific signals during observation and hence, that BA1/2 plays a causal role in the human MNS.

Original languageEnglish
Pages (from-to)1205-1217
Number of pages13
JournalSocial Cognitive and Affective Neuroscience
Volume11
Issue number8
DOIs
Publication statusPublished - 2016

Keywords

  • Action observation
  • BA1/2
  • Mirror neuron system
  • SI
  • TMS

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

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