Primary surgical cytoreduction in advanced ovarian cancer: An outcome analysis within the MITO (Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies) Group

Stefano Greggi, Francesca Falcone, Raffaele Carputo, Francesco Raspagliesi, Cono Scaffa, Giuseppe Laurelli, Giorgio Giorda, Giovanni Di Vagno, Francesco Petruzzelli, Gennaro Cormio, M. Marinaccio, Sandro Pignata

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Objective To draw a reliable picture of the surgical management of advanced ovarian cancer (AOC) within the MITO Group, trying to correlate the disease extent at presentation, the category of center, and surgical outcome. Methods Three tertiary referral centers for gynecologic oncology and four non-oncologic referral gynecologic surgical centers, participated in the project. A questionnaire was adopted to register perioperative data on AOCs (FIGO Stage IIIC-IV) consecutively operated on for a period of 12 months. Results A total of 205 patients were registered into the study: 140 and 65 were recruited in oncological referral centers and non-referral centers, respectively. Following a multivariate analysis, the Eisenkop score and the category of center resulted the most potent predictors of complete surgical cytoreduction followed by PCI, preoperative CA125, and ASA score. Complete surgical cytoreduction was associated with oncological referral centers (60% vs 24.6%, p <0.001). The proportion of patients undergoing additional surgical procedures was significantly different comparing the two categories of centers (at least one additional procedure was performed in 81.4% vs 50.8% in oncological referral centers compared to the others, p <0.001). Despite the more aggressive surgery performed in oncological referral centers, the perioperative outcome measures were not significantly different in the two groups. Conclusions The chance of obtaining a complete cytoreduction mainly depends on patient characteristics, tumor spread, and quality of treatment. The latter is amenable for direct influence, and therefore, seems to be of utmost importance when considering efforts aiming at improvement in the outcome of this disease.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalGynecologic Oncology
Issue number3
Publication statusPublished - Mar 1 2016


ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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