Primary systemic therapy for operable breast cancer: A review of clinical trials and perspectives

Valentina Guarneri, Antonio Frassoldati, Simona Giovannelli, Francesca Borghi, PierFranco Conte

Research output: Contribution to journalArticle

Abstract

Primary systemic therapy represents the standard of care for locally advanced breast cancer and has becoming an attractive alternative in earlier stages. A part from the proven advantage of increasing the rate of breast conservative surgery, the up front use of systemic therapy can allow for an in vivo test of treatment sensitivity, and response to primary treatment discriminates patients at different prognosis. This review will summarize the more relevant data on the preoperative treatment with chemotherapy, hormonal therapy and targeted agents.

Original languageEnglish
Pages (from-to)175-185
Number of pages11
JournalCancer Letters
Volume248
Issue number2
DOIs
Publication statusPublished - Apr 18 2007

Keywords

  • Breast cancer
  • Primary chemotherapy
  • Primary endocrine therapy
  • Primary targeted therapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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