Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject

G. F. Gaetani, A. M. Ferraris, S. Galiano, P. Giuntini, L. Canepa, M. d'Urso

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with primary thrombocythemia, who was heterozygous for glucose-6-phosphate dehydrogenase deficiency (Gd(B)/Gd(Med)), was investigated to test for the clonal origin of this myeloproliferative disorder. In order to assess somatic cell mosaicism in various tissues, we have made use of the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant: the results demonstrate that essential thrombocythemia is a clonal disease involving the erythrocytic, granulocytic, and megakaryocytic series, without affecting monocytes, T lymphocytes, and non-T lymphocytes.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalBlood
Volume59
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject'. Together they form a unique fingerprint.

Cite this