Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject

G. F. Gaetani, A. M. Ferraris, S. Galiano, P. Giuntini, L. Canepa, M. d'Urso

Research output: Contribution to journalArticle

Abstract

A patient with primary thrombocythemia, who was heterozygous for glucose-6-phosphate dehydrogenase deficiency (Gd(B)/Gd(Med)), was investigated to test for the clonal origin of this myeloproliferative disorder. In order to assess somatic cell mosaicism in various tissues, we have made use of the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant: the results demonstrate that essential thrombocythemia is a clonal disease involving the erythrocytic, granulocytic, and megakaryocytic series, without affecting monocytes, T lymphocytes, and non-T lymphocytes.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalBlood
Volume59
Issue number1
Publication statusPublished - 1982

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Essential Thrombocythemia
Glucosephosphate Dehydrogenase
Platelets
Granulocytes
Blood Platelets
Erythrocytes
Glucosephosphate Dehydrogenase Deficiency
Myeloproliferative Disorders
Glucose-6-Phosphate
Mosaicism
T-cells
Lymphocytes
Monocytes
Tissue
T-Lymphocytes
2-deoxyglucose-6-phosphate

ASJC Scopus subject areas

  • Hematology

Cite this

Gaetani, G. F., Ferraris, A. M., Galiano, S., Giuntini, P., Canepa, L., & d'Urso, M. (1982). Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject. Blood, 59(1), 76-79.

Primary thrombocythemia : Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject. / Gaetani, G. F.; Ferraris, A. M.; Galiano, S.; Giuntini, P.; Canepa, L.; d'Urso, M.

In: Blood, Vol. 59, No. 1, 1982, p. 76-79.

Research output: Contribution to journalArticle

Gaetani, GF, Ferraris, AM, Galiano, S, Giuntini, P, Canepa, L & d'Urso, M 1982, 'Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject', Blood, vol. 59, no. 1, pp. 76-79.
Gaetani GF, Ferraris AM, Galiano S, Giuntini P, Canepa L, d'Urso M. Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject. Blood. 1982;59(1):76-79.
Gaetani, G. F. ; Ferraris, A. M. ; Galiano, S. ; Giuntini, P. ; Canepa, L. ; d'Urso, M. / Primary thrombocythemia : Clonal origin of platelets, erythrocytes, and granulocytes in a Gd(B)/Gd(Mediterranean) subject. In: Blood. 1982 ; Vol. 59, No. 1. pp. 76-79.
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