Abstract
Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).
| Original language | English |
|---|---|
| Pages (from-to) | 225-230 |
| Number of pages | 6 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 20 |
| Issue number | 2 |
| Publication status | Published - 2001 |
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Keywords
- Oral cancer
- P53 and CD34 expression
- Prognosis
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients. / Grammatica, L.; Piepoli, S.; D'Auria, C.; Achille, G.; Marzullo, F.; Zito, F. A.; Labriola, A.; Salvatore, C.; Paradiso, A.
In: Journal of Experimental and Clinical Cancer Research, Vol. 20, No. 2, 2001, p. 225-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients
AU - Grammatica, L.
AU - Piepoli, S.
AU - D'Auria, C.
AU - Achille, G.
AU - Marzullo, F.
AU - Zito, F. A.
AU - Labriola, A.
AU - Salvatore, C.
AU - Paradiso, A.
PY - 2001
Y1 - 2001
N2 - Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).
AB - Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).
KW - Oral cancer
KW - P53 and CD34 expression
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=0034939751&partnerID=8YFLogxK
M3 - Article
VL - 20
SP - 225
EP - 230
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 2
ER -