Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients

L. Grammatica, S. Piepoli, C. D'Auria, G. Achille, F. Marzullo, F. A. Zito, A. Labriola, C. Salvatore, A. Paradiso

Research output: Contribution to journalArticlepeer-review

Abstract

Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Volume20
Issue number2
Publication statusPublished - 2001

Keywords

  • Oral cancer
  • P53 and CD34 expression
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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