Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients

L. Grammatica, S. Piepoli, C. D'Auria, G. Achille, F. Marzullo, F. A. Zito, A. Labriola, C. Salvatore, A. Paradiso

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Volume20
Issue number2
Publication statusPublished - 2001

Fingerprint

Carcinoma
Microvessels
Survival
Neoplasms
Paraffin
Squamous Cell Carcinoma
Multivariate Analysis

Keywords

  • Oral cancer
  • P53 and CD34 expression
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients. / Grammatica, L.; Piepoli, S.; D'Auria, C.; Achille, G.; Marzullo, F.; Zito, F. A.; Labriola, A.; Salvatore, C.; Paradiso, A.

In: Journal of Experimental and Clinical Cancer Research, Vol. 20, No. 2, 2001, p. 225-230.

Research output: Contribution to journalArticle

Grammatica, L, Piepoli, S, D'Auria, C, Achille, G, Marzullo, F, Zito, FA, Labriola, A, Salvatore, C & Paradiso, A 2001, 'Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients', Journal of Experimental and Clinical Cancer Research, vol. 20, no. 2, pp. 225-230.
Grammatica, L. ; Piepoli, S. ; D'Auria, C. ; Achille, G. ; Marzullo, F. ; Zito, F. A. ; Labriola, A. ; Salvatore, C. ; Paradiso, A. / Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients. In: Journal of Experimental and Clinical Cancer Research. 2001 ; Vol. 20, No. 2. pp. 225-230.
@article{7c7c1b89a4a54bdbacdb8c8d84cbbefb,
title = "Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients",
abstract = "Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21{\%} of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95{\%} C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95{\%} C.I. 0.96-6.5; p=0.06).",
keywords = "Oral cancer, P53 and CD34 expression, Prognosis",
author = "L. Grammatica and S. Piepoli and C. D'Auria and G. Achille and F. Marzullo and Zito, {F. A.} and A. Labriola and C. Salvatore and A. Paradiso",
year = "2001",
language = "English",
volume = "20",
pages = "225--230",
journal = "Journal of Experimental and Clinical Cancer Research",
issn = "0392-9078",
publisher = "BioMed Central Ltd.",
number = "2",

}

TY - JOUR

T1 - Primary tumours neoangiogenesis and p53 expression in oral carcinoma patients

AU - Grammatica, L.

AU - Piepoli, S.

AU - D'Auria, C.

AU - Achille, G.

AU - Marzullo, F.

AU - Zito, F. A.

AU - Labriola, A.

AU - Salvatore, C.

AU - Paradiso, A.

PY - 2001

Y1 - 2001

N2 - Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).

AB - Paraffin embebbed tumour tissues from 47 T1-2N0-1M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).

KW - Oral cancer

KW - P53 and CD34 expression

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=0034939751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034939751&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 225

EP - 230

JO - Journal of Experimental and Clinical Cancer Research

JF - Journal of Experimental and Clinical Cancer Research

SN - 0392-9078

IS - 2

ER -