Primary yolk sac tumor of the liver: Incidental finding in a patient transplanted for hepatocellular carcinoma

Ilaria Lenci, Laura Tariciotti, Leonardo Baiocchi, Tommaso Maria Manzia, Luca Toti, Paolo Craboledda, Francesco Callea, Mario Angelico, Giuseppe Tisone

Research output: Contribution to journalArticle

Abstract

A 64-year-old man with HBV-related cirrhosis presented with a liver nodule measuring 2.8 cm revealed by a routine ultrasound and concomitant increased alpha-fetoprotein (AFP) up to 400 UI/l. Contrast-enhanced CT was suggestive of hepatocellular carcinoma (HCC) and the patient underwent laser ablation procedure. Five months later, because of raised AFP up to 1600 UI/l, ultrasonography and abdominal CT were repeated, showing an increased diameter of liver nodule, measuring 3.8 cm. The patient underwent down-staged trans-arterial chemoembolization (TACE) and then was entered into the active liver transplant (LT) list. Lamivudine was already started and the patient underwent LT showing HBV-DNA serum levels 3 log/copies at the time of surgery. Pathological analysis performed on the explanted liver showed, instead of the suspected HCC, hepatic yolk sac tumor with the presence of typical 'Schiller-Duval bodies'. The first 12 months of postoperative follow-up were excellent, with no evidence of tumor recurrence.

Original languageEnglish
Pages (from-to)598-601
Number of pages4
JournalTransplant International
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Hepatocellular carcinoma
  • Liver transplantation
  • Yolk sac tumor

ASJC Scopus subject areas

  • Transplantation

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    Lenci, I., Tariciotti, L., Baiocchi, L., Manzia, T. M., Toti, L., Craboledda, P., Callea, F., Angelico, M., & Tisone, G. (2008). Primary yolk sac tumor of the liver: Incidental finding in a patient transplanted for hepatocellular carcinoma. Transplant International, 21(6), 598-601. https://doi.org/10.1111/j.1432-2277.2008.00667.x