Primate immunoglobulin heavy chain constant gamma genes: an hypothesis of their evolution

A. Brusco, A. O. Carbonara, S. Crovella, A. Bottaro

Research output: Contribution to journalArticle

Abstract

Four Immunoglobulin gamma heavy chain isotypes are present in humans; the true phylogenetic relationship between the genes are not known because of the complex concerted evolution of the Ig multigene locus. Here we present data obtained from Southern blot analysis of the gamma genes in several primate species including prosimians (Lemur catta), New World Monkeys (Saguinus oedipus) and Old World Monkeys (Cercopitecus aethiops and Macaca fascicularis). Our data show the presence of a single IgG gene in Lemur and probably in S.l oedipus, and of multiple genes in the two Cercopithecinae. These findings suggest that a single IgG gene was present in the ancestor of primates: we suppose that this IgG gene was later duplicated several times during primate evolution.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalHuman Evolution
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1998

Fingerprint

Immunoglobulin gamma-Chains
immunoglobulin heavy chains
primate
Primates
gene
Lemur
Genes
genes
Immunoglobulin G
Cercopithecinae
Saguinus
Strepsirhini
Platyrrhini
Cercopithecidae
Saguinus oedipus
concerted evolution
Cebidae
Macaca fascicularis
Southern Blotting
ancestry

Keywords

  • evolution
  • IgHC
  • Primates

ASJC Scopus subject areas

  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Primate immunoglobulin heavy chain constant gamma genes : an hypothesis of their evolution. / Brusco, A.; Carbonara, A. O.; Crovella, S.; Bottaro, A.

In: Human Evolution, Vol. 13, No. 1, 01.1998, p. 49-56.

Research output: Contribution to journalArticle

Brusco, A. ; Carbonara, A. O. ; Crovella, S. ; Bottaro, A. / Primate immunoglobulin heavy chain constant gamma genes : an hypothesis of their evolution. In: Human Evolution. 1998 ; Vol. 13, No. 1. pp. 49-56.
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