Plasma primidone (PRM) and derived phenobarbitone (PB) concentrations were monitored in 15 newborns of epileptic mothers treated throughout pregnancy with PRM on monotherapy. Blood samples were taken at birth and daily up to the 12th day. Good correlations were found between newborn and maternel plasma concentrations both for PRM and for derived PB. In most newborns PRM was eliminated according to a 1st order process, whereas derived PB showed irregular and slow disappearance. PRM apparent plasma half-life was calculated in 12 newborns (range: 9-53 hrs); no statistically significant difference was observed between breast-fed and bottle-fed newborns. No relevant clinical effect was observed in newborns related to PRM mothers' treatment.
|Translated title of the contribution||Primidone: Placental transfer and elimination from the newborn|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Clinical Neurology