Priming as a model of behavioural sensitization

G. Di Chiara, M. Morelli, P. Barone, F. Pontieri

Research output: Contribution to journalArticlepeer-review

Abstract

Repeated exposure to drugs acting as direct or indirect stimulants of central dopamine transmission results in sensitization to their behavioural stimulant properties (behavioural sensitization). Priming provides a simple model of behavioural sensitization particularly suitable for studies of its neural and molecular mechanisms. The results obtained to date indicate that priming results in an increased responsiveness of postsynaptic dopamine receptor mechanisms in the caudate nucleus, possibly due to an increased affinity of the D-1 receptor for its agonist.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalDevelopmental Pharmacology and Therapeutics
Volume18
Issue number3-4
Publication statusPublished - 1992

Keywords

  • Basal ganglia
  • Behaviour
  • Dopamine
  • Priming
  • Sensitization

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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