Principles of NK cell/DC crosstalk: The importance of cell dialogue for a protective immune response

Gabrielle Lui; Paolo Carrega; Guido Ferlazzo

doi:10.1159/000090197

Principles of NK cell/DC crosstalk: The importance of cell dialogue for a protective immune response

Gabrielle Lui, Paolo Carrega, Guido Ferlazzo

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

A cooperative dialogue between natural killer (NK) cells and dendritic cells (DCs) has been recently described. They help each other to acquire their complete functions, both in the periphery and in the secondary lymphoid organs. In vitro, IL-12, IL-18, IL-15, and type-I IFN are implicated in the activation, proliferation, and cytotoxicity of NK cells by mature DCs, while TNF-α secreted by NK cells is involved in the maturation of DCs. Not completely clarified cell-to-cell contacts are also implicated in this cross-talk. Thus, NK cell activation allows the killing of transformed or infected cells in the periphery, but may also be important for the generation of adaptive immunity. Recent works suggest that they may play a key role in polarizing a Th1 response. This dialogue between DCs and NK cells may be further exploited in immunotherapy aimed to boost immune response.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Transfusion Medicine and Hemotherapy
Volume	33
Issue number	1
DOIs	https://doi.org/10.1159/000090197
Publication status	Published - Jan 2006

Keywords

Dendritic cells
Lymph nodes
Natural killer cells
Neoplasm

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Immunology and Allergy
Hematology

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Principles of NK cell/DC crosstalk: The importance of cell dialogue for a protective immune response

Abstract

Keywords

ASJC Scopus subject areas

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