Abstract
A cooperative dialogue between natural killer (NK) cells and dendritic cells (DCs) has been recently described. They help each other to acquire their complete functions, both in the periphery and in the secondary lymphoid organs. In vitro, IL-12, IL-18, IL-15, and type-I IFN are implicated in the activation, proliferation, and cytotoxicity of NK cells by mature DCs, while TNF-α secreted by NK cells is involved in the maturation of DCs. Not completely clarified cell-to-cell contacts are also implicated in this cross-talk. Thus, NK cell activation allows the killing of transformed or infected cells in the periphery, but may also be important for the generation of adaptive immunity. Recent works suggest that they may play a key role in polarizing a Th1 response. This dialogue between DCs and NK cells may be further exploited in immunotherapy aimed to boost immune response.
| Original language | English |
|---|---|
| Pages (from-to) | 50-57 |
| Number of pages | 8 |
| Journal | Transfusion Medicine and Hemotherapy |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2006 |
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Keywords
- Dendritic cells
- Lymph nodes
- Natural killer cells
- Neoplasm
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Immunology and Allergy
- Hematology
Cite this
Principles of NK cell/DC crosstalk : The importance of cell dialogue for a protective immune response. / Lui, Gabrielle; Carrega, Paolo; Ferlazzo, Guido.
In: Transfusion Medicine and Hemotherapy, Vol. 33, No. 1, 01.2006, p. 50-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Principles of NK cell/DC crosstalk
T2 - The importance of cell dialogue for a protective immune response
AU - Lui, Gabrielle
AU - Carrega, Paolo
AU - Ferlazzo, Guido
PY - 2006/1
Y1 - 2006/1
N2 - A cooperative dialogue between natural killer (NK) cells and dendritic cells (DCs) has been recently described. They help each other to acquire their complete functions, both in the periphery and in the secondary lymphoid organs. In vitro, IL-12, IL-18, IL-15, and type-I IFN are implicated in the activation, proliferation, and cytotoxicity of NK cells by mature DCs, while TNF-α secreted by NK cells is involved in the maturation of DCs. Not completely clarified cell-to-cell contacts are also implicated in this cross-talk. Thus, NK cell activation allows the killing of transformed or infected cells in the periphery, but may also be important for the generation of adaptive immunity. Recent works suggest that they may play a key role in polarizing a Th1 response. This dialogue between DCs and NK cells may be further exploited in immunotherapy aimed to boost immune response.
AB - A cooperative dialogue between natural killer (NK) cells and dendritic cells (DCs) has been recently described. They help each other to acquire their complete functions, both in the periphery and in the secondary lymphoid organs. In vitro, IL-12, IL-18, IL-15, and type-I IFN are implicated in the activation, proliferation, and cytotoxicity of NK cells by mature DCs, while TNF-α secreted by NK cells is involved in the maturation of DCs. Not completely clarified cell-to-cell contacts are also implicated in this cross-talk. Thus, NK cell activation allows the killing of transformed or infected cells in the periphery, but may also be important for the generation of adaptive immunity. Recent works suggest that they may play a key role in polarizing a Th1 response. This dialogue between DCs and NK cells may be further exploited in immunotherapy aimed to boost immune response.
KW - Dendritic cells
KW - Lymph nodes
KW - Natural killer cells
KW - Neoplasm
UR - http://www.scopus.com/inward/record.url?scp=33644525945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644525945&partnerID=8YFLogxK
U2 - 10.1159/000090197
DO - 10.1159/000090197
M3 - Article
AN - SCOPUS:33644525945
VL - 33
SP - 50
EP - 57
JO - Transfusion Medicine and Hemotherapy
JF - Transfusion Medicine and Hemotherapy
SN - 1660-3796
IS - 1
ER -