Prion Deposition in Olfactory Biopsy of Sporadic Creutzfeldt-Jakob Disease

Massimo Tabaton, Salvatore Monaco, Maria Paola Cordone, Monica Colucci, Giorgio Giaccone, Fabrizio Tagliavini, Gianluigi Zanusso

Research output: Contribution to journalArticlepeer-review


Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt-Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt-Jakob disease.

Original languageEnglish
Pages (from-to)294-296
Number of pages3
JournalAnnals of Neurology
Issue number2
Publication statusPublished - Feb 2004

ASJC Scopus subject areas

  • Neuroscience(all)


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