Prion disease in dromedary camels, Algeria

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Prions cause fatal and transmissible neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in small ruminants, and bovine spongiform encephalopathy (BSE). After the BSE epidemic, and the associated human infections, began in 1996 in the United Kingdom, general concerns have been raised about animal prions. We detected a prion disease in dromedary camels (Camelus dromedarius) in Algeria. Symptoms suggesting prion disease occurred in 3.1% of dromedaries brought for slaughter to the Ouargla abattoir in 2015–2016. We confirmed diagnosis by detecting pathognomonic neurodegeneration and disease-specific prion protein (PrPSc) in brain tissues from 3 symptomatic animals. Prion detection in lymphoid tissues is suggestive of the infectious nature of the disease. PrPSc biochemical characterization showed differences with BSE and scrapie. Our identification of this prion disease in a geographically widespread livestock species requires urgent enforcement of surveillance and assessment of the potential risks to human and animal health.

Original languageEnglish
Pages (from-to)1029-1036
Number of pages8
JournalEmerging Infectious Diseases
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

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Algeria
Camelus
Prion Diseases
Bovine Spongiform Encephalopathy
Prions
Scrapie
Creutzfeldt-Jakob Syndrome
Abattoirs
Ruminants
Livestock
Lymphoid Tissue
Neurodegenerative Diseases
Communicable Diseases
Health
Brain
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Prion disease in dromedary camels, Algeria. / Babelhadj, Baaissa; Di Bari, Michele Angelo; Pirisinu, Laura; Chiappini, Barbara; Gaouar, Semir Bechir Suheil; Riccardi, Geraldina; Marcon, Stefano; Agrimi, Umberto; Nonno, Romolo; Vaccari, Gabriele.

In: Emerging Infectious Diseases, Vol. 24, No. 6, 01.06.2018, p. 1029-1036.

Research output: Contribution to journalArticle

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