Prion Disorders and Sleep

Pasquale Montagna; Federica Provini

doi:10.1016/j.jsmc.2008.04.009

Prion Disorders and Sleep

Pasquale Montagna, Federica Provini

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.

Original language	English
Pages (from-to)	411-426
Number of pages	16
Journal	Sleep Medicine Clinics
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/j.jsmc.2008.04.009
Publication status	Published - Sep 2008

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Clinical Psychology
Neuropsychology and Physiological Psychology

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10.1016/j.jsmc.2008.04.009

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abstract = "Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.",

author = "Pasquale Montagna and Federica Provini",

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Prion Disorders and Sleep

Abstract

ASJC Scopus subject areas

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