Prion Disorders and Sleep

Pasquale Montagna, Federica Provini

Research output: Contribution to journalArticlepeer-review

Abstract

Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.

Original languageEnglish
Pages (from-to)411-426
Number of pages16
JournalSleep Medicine Clinics
Volume3
Issue number3
DOIs
Publication statusPublished - Sep 2008

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuropsychology and Physiological Psychology

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