Abstract
Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.
| Original language | English |
|---|---|
| Pages (from-to) | 411-426 |
| Number of pages | 16 |
| Journal | Sleep Medicine Clinics |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Clinical Psychology
- Neuropsychology and Physiological Psychology
Cite this
Prion Disorders and Sleep. / Montagna, Pasquale; Provini, Federica.
In: Sleep Medicine Clinics, Vol. 3, No. 3, 09.2008, p. 411-426.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prion Disorders and Sleep
AU - Montagna, Pasquale
AU - Provini, Federica
PY - 2008/9
Y1 - 2008/9
N2 - Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.
AB - Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.
UR - http://www.scopus.com/inward/record.url?scp=64749096868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64749096868&partnerID=8YFLogxK
U2 - 10.1016/j.jsmc.2008.04.009
DO - 10.1016/j.jsmc.2008.04.009
M3 - Article
AN - SCOPUS:64749096868
VL - 3
SP - 411
EP - 426
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
SN - 1556-407X
IS - 3
ER -