Abstract
Sleep disturbances are diagnostically relevant in the investigation of human prion diseases. Fatal familial insomnia is characterized by loss of slow-wave sleep, abnormal rapid eye movement (REM) states, and autonomic and motor hyperactivity without circadian rhythmicity. Abnormal REM sleep and deterioration of sleep organization also are found in sporadic Creutzfeldt-Jakob disease. Altered sleep also features in many prion diseases of animals, and prion diseases represent interesting models for sleep pathophysiology.
Original language | English |
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Pages (from-to) | 411-426 |
Number of pages | 16 |
Journal | Sleep Medicine Clinics |
Volume | 3 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sep 2008 |
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Clinical Psychology
- Neuropsychology and Physiological Psychology