Prion protein gene M129V polymorphism and variability in age at migraine onset

Raffaele Palmirotta, Giorgia Ludovici, Gabriella Egeo, Cristiano Ialongo, Cinzia Aurilia, Luisa Fofi, Maria Laura De Marchis, David Della-Morte, Piero Barbanti, Fiorella Guadagni

Research output: Contribution to journalArticlepeer-review


Prion protein, a sialoglycoprotein with neuroprotective properties on oxidative stress damage, has been related with the mechanisms leading to migraine. In the present case-control study, we investigated the correlation between the common methionine/valine polymorphism at codon 129 within the prion protein gene (PRNP) and migraine. Genotyping of PRNP V129M variant was performed in 384 migraine patients and 185 age-, sex-, and race-ethnicity-matched healthy controls. The frequencies of the PRNP V129M genotype did not differ significantly between migraineurs and controls. The frequencies of 129VV genotype were significantly higher in patients with earlier age at migraine onset. No correlation was found between PRNP 129 genotype and demographics, and other clinical migraine features. Our data suggest that the PRNP 129VV polymorphism is not a direct migraine risk factor but is significantly associated with an earlier onset of the disease.

Original languageEnglish
Pages (from-to)540-545
Number of pages6
Issue number3
Publication statusPublished - Mar 2013


  • genetic polymorphism
  • migraine
  • oxidative stress
  • prion protein

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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