Le priorità associate all'uso dei farmaci "off-label": Il punto di vista del pediatra ospedaliero

Translated title of the contribution: Priorities among off-label prescriptions: Paediatricians' perspective

Federico Marchetti, J. Bua, S. Demarini, R. Devescovi, C. Germani, P. Mergoni, G. Messi, M. Pennesi, M. Rabusin, A. Sarti, A. Ventura, A. Arrighini, G. Chirico, M. Duse, N. Miguetti, M. S. Molinaro, L. D. Notarangelo, F. Porta, V. Porteri, E. SonciniR. F. Schumacher, S. Di Maio, L. Di Martino, L. Giordano, F. De Leva, C. Pecoraro, M. Baldi, E. Banaudi, S. Einaudi, G. Migliore, P. Pecco, P. Saracco, A. Tocchet, M. Bonati

Research output: Contribution to journalArticlepeer-review


Two thirds of the drugs prescribed for children are off-label. However, off-label is not synonymous with incorrect, since it often represents the most rational, evidence-based therapy. Existing data on the use of off-label in children are based on prescriptions registers. The aim of our study was to investigate the paediatricians' perspective on off-label use in their everyday hospital practice. Four Paediatrics Italian Hospitals were involved in the study. Questionnaires covered eight different department/speciality units. Our findings showed that the most common reasons detected for off-label use were formulation and age. Corticosteroids, antihypertensive drugs and midazolam were most frequently indicated as off-label for formulation, while ciprofloxacin, new generation anti-epilepsy drugs (lamotrigine, oxcarbazepine) and immunosuppressant (mycophenolate, rituximab) for age. The drugs identified as off-label differed according to department, although some recurred (i.e. ACE inhibitors, ketorolac). Our survey might be of help for planning appropriate interventions to tackle the problem of off-label use in paediatrics.

Translated title of the contributionPriorities among off-label prescriptions: Paediatricians' perspective
Original languageItalian
Pages (from-to)527-531
Number of pages5
JournalMedico e Bambino
Issue number8
Publication statusPublished - Oct 31 2005

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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