Prioritization and analysis of pharmaceuticals for human use contaminating the aquatic ecosystem in Italy

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16 Citations (Scopus)

Abstract

A predictive approach is needed to study pharmaceuticals and their loads in the environment so as to restrict monitoring to the molecules most likely to occur widely. A three steps method has been developed for this purpose. The first step is to establish the Predicted Environmental Concentrations (PECs) following the approach proposed by the European Medicines Agency (EMA); then the list is refined taking account of metabolic rates and excretion of the parent compounds in humans. In the third stage the substances are sorted according to their fate in sewage treatment plants (STPs). Finally, the results are compared with real concentrations of the pharmaceuticals in surface waters analyzed by HPLC-MS/MS techniques. This paper reports results of this predictive approach in 2013 for Italy.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume106
DOIs
Publication statusPublished - Mar 5 2015

Fingerprint

Aquatic ecosystems
Italy
Ecosystem
Sewage treatment plants
Sewage
Surface waters
Pharmaceutical Preparations
Medicine
High Pressure Liquid Chromatography
Molecules
Water
Monitoring

Keywords

  • Mass spectrometry
  • Measured environmental concentration (MEC)
  • Pharmaceuticals
  • Predicted environmental concentration (PEC)
  • Sewage treatment plant (STP)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

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abstract = "A predictive approach is needed to study pharmaceuticals and their loads in the environment so as to restrict monitoring to the molecules most likely to occur widely. A three steps method has been developed for this purpose. The first step is to establish the Predicted Environmental Concentrations (PECs) following the approach proposed by the European Medicines Agency (EMA); then the list is refined taking account of metabolic rates and excretion of the parent compounds in humans. In the third stage the substances are sorted according to their fate in sewage treatment plants (STPs). Finally, the results are compared with real concentrations of the pharmaceuticals in surface waters analyzed by HPLC-MS/MS techniques. This paper reports results of this predictive approach in 2013 for Italy.",
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