PRL-3: A phosphatase for metastasis?

Jason A. Sager, Silvia Benvenuti, Alberto Bardelli

Research output: Contribution to journalArticlepeer-review


The PRL-3 phosphatase has joined the cancer arena very recently but is rapidly gaining interest both as a putative prognostic factor and as a therapeutic target for metastatic tumors. In this issue Guo and colleagues provide another key piece of information by showing that the catalytic activity of PRL-3 is required for experimental metastasis formation in mouse models. Here we summarize the current knowledge and discuss what remains to be done before PRL-3 could be considered as a target for diagnostics or therapeutics in the clinical setting of human cancer.

Original languageEnglish
Pages (from-to)952-953
Number of pages2
JournalCancer Biology and Therapy
Issue number10
Publication statusPublished - Oct 2004


  • Adhesion
  • Breast cancer
  • Colon cancer
  • Endothelium
  • Gastric cancer
  • Gene overexpression
  • Invasion
  • Metastasis
  • Motility
  • Phosphatase
  • Prenylation
  • PRL-1
  • PRL-2
  • PRL-3
  • Signal transduction
  • Therapeutic target
  • Transcriptional analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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