PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

Research output: Contribution to journalArticlepeer-review

Abstract

Protein arginine methyltransferase 1 (PRMT1) overexpression is linked to cancer chemoresistance, but the mechanism is still unclear. Musiani et al. show that, upon cisplatin, PRMT1 is recruited by DNA-dependent protein kinase (DNA-PK) to chromatin, where it sustains the transcription of genes involved in the senescence-associated secretory phenotype (SASP), thus protecting cells from drug-induced apoptosis.

Original languageEnglish
Pages (from-to)1208-1222.e9
JournalCell Reports
Volume30
Issue number4
DOIs
Publication statusPublished - Jan 28 2020

Keywords

  • arginine methylation
  • cisplatin
  • DNA-PK
  • epigenetic drugs
  • MS-based proteomics
  • PRMT1
  • replication stress response
  • SASP
  • transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin'. Together they form a unique fingerprint.

Cite this