PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

Daniele Musiani, Roberto Giambruno, Enrico Massignani, Marica Rosaria Ippolito, Marianna Maniaci, Sriganesh Jammula, Daria Manganaro, Alessandro Cuomo, Luciano Nicosia, Diego Pasini, Tiziana Bonaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Protein arginine methyltransferase 1 (PRMT1) overexpression is linked to cancer chemoresistance, but the mechanism is still unclear. Musiani et al. show that, upon cisplatin, PRMT1 is recruited by DNA-dependent protein kinase (DNA-PK) to chromatin, where it sustains the transcription of genes involved in the senescence-associated secretory phenotype (SASP), thus protecting cells from drug-induced apoptosis.

Original languageEnglish
Pages (from-to)1208-1222.e9
JournalCell Reports
Volume30
Issue number4
DOIs
Publication statusPublished - Jan 28 2020

Keywords

  • arginine methylation
  • cisplatin
  • DNA-PK
  • epigenetic drugs
  • MS-based proteomics
  • PRMT1
  • replication stress response
  • SASP
  • transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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