Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study

N Veronese, B Stubbs, A Koyanagi, J R Hébert, C Cooper, M G Caruso, G Guglielmi, J Y Reginster, R Rizzoli, S Maggi, N Shivappa

Research output: Contribution to journalArticlepeer-review


In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders.

INTRODUCTION: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people.

METHODS: This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs).

RESULTS: During 8 years of follow-up, 560 individuals developed fractures (15.4%). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95% CI = 1.02-2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02-1.27). The association between DII score and fractures was not significant among men or in the sample as whole.

CONCLUSION: Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalOsteoporosis International
Publication statusE-pub ahead of print - Oct 10 2017


  • Journal Article


Dive into the research topics of 'Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study'. Together they form a unique fingerprint.

Cite this