Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects

Robertina Giacconi, Calogero Caruso, Marco Malavolta, Domenico Lio, Carmela R. Balistreri, Letizia Scola, Giuseppina Candore, Elisa Muti, Eugenio Mocchegiani

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Inflammation and genetics are prominent mechanisms in the pathogenesis of atherosclerosis (AT) and its complications. In this review we discuss the possible impact on AT development of several genetic determinants involved in inflammation, oxidative stress and cytoprotection (IL-6, TNF-α, IL-10, CD14, TLR4, MT, HSP70). Genetic polymorphisms of these genes may affect a differential inflammatory response predisposing to AT. However, allelic polymorphisms of genes which increase the risk of AT frequently occur in the general population but, only adequate gene-environment-polymorphism interactions promote the onset of the disease. Zinc deficiency has been suggested as an environmental risk factor for AT. With advancing age, the incidence of zinc deficiency increases for several reasons. Among them, dietary intake, malabsorption and genetic background of inflammatory markers may be involved. A crucial contribution may also be played by increased oxidative stress which may lead to the appearance of dysfunctional proteins, including metallothioneins (MT) that are in turn involved in zinc homeostasis. The detection of candidate genes related to inflammation and promoting AT and their reciprocal influence/interaction with zinc status might allow earlier appropriate dietary interventions in genetically susceptible subjects.

Original languageEnglish
Pages (from-to)306-318
Number of pages13
JournalAgeing Research Reviews
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Zinc
Atherosclerosis
Genes
Polymorphism
Oxidative stress
Metallothionein
Inflammation
Oxidative Stress
Interleukin-10
Interleukin-6
Gene-Environment Interaction
Cytoprotection
Genetic Polymorphisms
Genetic Background
Homeostasis
Proteins
Incidence
Population

Keywords

  • Atherosclerosis
  • Elderly
  • Inflammation
  • Polymorphisms
  • Zinc status

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects. / Giacconi, Robertina; Caruso, Calogero; Malavolta, Marco; Lio, Domenico; Balistreri, Carmela R.; Scola, Letizia; Candore, Giuseppina; Muti, Elisa; Mocchegiani, Eugenio.

In: Ageing Research Reviews, Vol. 7, No. 4, 12.2008, p. 306-318.

Research output: Contribution to journalArticle

Giacconi, R, Caruso, C, Malavolta, M, Lio, D, Balistreri, CR, Scola, L, Candore, G, Muti, E & Mocchegiani, E 2008, 'Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects', Ageing Research Reviews, vol. 7, no. 4, pp. 306-318. https://doi.org/10.1016/j.arr.2008.06.001
Giacconi, Robertina ; Caruso, Calogero ; Malavolta, Marco ; Lio, Domenico ; Balistreri, Carmela R. ; Scola, Letizia ; Candore, Giuseppina ; Muti, Elisa ; Mocchegiani, Eugenio. / Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects. In: Ageing Research Reviews. 2008 ; Vol. 7, No. 4. pp. 306-318.
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