Pro-oxidant activity and methionine metabolism in chronic alcohol abusers: Relationship to alcohol withdrawal and folate administration

R. Trotti, M. Carratelli, P. Bo, M. Barbieri, A. Mangiagalli, A. Samuele, E. Gabanti, F. Blandini

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. The aim of this study was to investigate whether alcohol withdrawal and folate administration could play a role on redox balance and metionine metabolism in heavy drinkers. Methods. The derivatives of reactive oxygen metabolites (d-ROMs), homocysteine, total thiols, vitamin B12 and folate were evaluated in a selected group of 40 consecutive chronic alcohol abusers by comparison with 44 healthy moderate drinkers, as controls. Results. Before alcohol withdrawal, d-ROMs were significantly higher (p12 levels: 487 (299-786) pg/mL 621 (243-894) pg/mL. A negative correlation between homocysteine and folate was observed before withdrawal in alcoholics (r=-0.4546, p

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalPanminerva Medica
Volume46
Issue number3
Publication statusPublished - Sep 2004

Keywords

  • Alcohol
  • Folic acid
  • Homocysteine
  • Oxidative stress
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Pro-oxidant activity and methionine metabolism in chronic alcohol abusers: Relationship to alcohol withdrawal and folate administration'. Together they form a unique fingerprint.

Cite this