ProAD: A web tool for the automatic assessment of prodromal Alzheimer's disease

Luca Rei, Mario Esposito, Paolo Bosco, Mirko Corosu, Andrea Chincarini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present the development of a web-based interface (proAD) for the automatic analysis of structural T1-weighted magnetic resonance images (MRI). This web-based tool is meant to be a high level interface to a sophisticated analysis environment aimed at the early diagnosis of Alzheimer's disease patients. The analysis procedure relies on clinical diagnosis and follow up data. It extracts several portions of the temporal lobe, mainly around the hippocampal area, and processes them with no interactive input from the user. The output of the MRI analysis is a classification index which is able to distinguish among: (a) patients with Alzheimer's disease (AD), (b) patients with amnestic mild cognitive impairment (aMCI), (c) patients with amnestic mild cognitive impairment who are likely to develop AD in a time frame of 2 years (aMCIconv), and (c) normal cognitive subjects. The interface is still under development and has been built as easy and user-friendly as possible. Robustness has been considered as essential part for the development. Results are presented to users in a very simple manner, thereby serving as a potential diagnostic tool for neurologists. A working testbed of proAD (still in alpha stage) can be reached at http://magic5gui.ge.infn.it/tesi

Original languageEnglish
Title of host publicationMeMeA 2011 - 2011 IEEE International Symposium on Medical Measurements and Applications, Proceedings
DOIs
Publication statusPublished - 2011
Event2011 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2011 - Bari, Italy
Duration: May 30 2011May 31 2011

Other

Other2011 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2011
CountryItaly
CityBari
Period5/30/115/31/11

ASJC Scopus subject areas

  • Biomedical Engineering

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