Proanthocyanidins and the risk of prostate cancer in Italy

Delphine Praud, Maria Parpinel, Valentina Guercio, Cristina Bosetti, Diego Serraino, Gaetano Facchini, Maurizio Montella, Carlo La Vecchia, Marta Rossi

Research output: Contribution to journalArticle

Abstract

Proanthocyanidins are polymers of monomeric unit flavan-3-ols with antioxidant, anti-inflammatory and free radical scavenging activities. We investigated the association between proanthocyanidin intake and prostate cancer risk through data that were collected between 1991 and 2002 in an Italian case-control study, including a total of 1,294 incident, histologically confirmed cases of prostate cancer and 1,451 controls admitted to hospital for acute, non-neoplastic, and non-hormone-related diseases. We estimated odds ratios (ORs) and their 95% confidence intervals (CIs) using multiple logistic regression models, and computed energy-adjusted proanthocyanidin intakes using the residual method. The ORs for the highest versus the lowest tertile were 0.80 (95% CI 0.83-1.00) for energy-adjusted monomers and dimers combined, 0.72 (95% CI 0.59-0.87) for polymers with ≥ 3 mers, and 0.72 (95% CI 0.59-0.88) for total proanthocyanidins. The inverse relation was stronger among cases with a Gleason score ≥ 7, with the ORs of 0.56 (95% CI 0.40-0.78) for monomers and dimers, 0.62 (95% CI 0.40-0.78) for polymers with ≥ 3 mers, and 0.57 (95% CI 0.42-0.77) for total proanthocyanidins. These risk estimates were consistent across strata of age, education, body mass index, and family history of prostate cancer. Our data indicate an inverse association between proanthocyanidins and prostate cancer risk.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalCancer Causes and Control
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2018

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Proanthocyanidins
Italy
Prostatic Neoplasms
Confidence Intervals
Polymers
Odds Ratio
Logistic Models
Free Radicals
Case-Control Studies
Body Mass Index
Anti-Inflammatory Agents
Antioxidants
Education

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Proanthocyanidins and the risk of prostate cancer in Italy. / Praud, Delphine; Parpinel, Maria; Guercio, Valentina; Bosetti, Cristina; Serraino, Diego; Facchini, Gaetano; Montella, Maurizio; La Vecchia, Carlo; Rossi, Marta.

In: Cancer Causes and Control, Vol. 29, No. 2, 02.2018, p. 261-268.

Research output: Contribution to journalArticle

Praud, Delphine ; Parpinel, Maria ; Guercio, Valentina ; Bosetti, Cristina ; Serraino, Diego ; Facchini, Gaetano ; Montella, Maurizio ; La Vecchia, Carlo ; Rossi, Marta. / Proanthocyanidins and the risk of prostate cancer in Italy. In: Cancer Causes and Control. 2018 ; Vol. 29, No. 2. pp. 261-268.
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