Abstract
Objective: To estimate the cumulative probability of developing gallstones and to evaluate possible risk factors in a large series of Italian cirrhotic patients, free of gallstones at enrolment. Setting: Gastroenterology unit at a Milan teaching hospital and four general hospitals in northern Italy. Patients: The study included 400 consecutive cirrhotic patients (257 men and 143 women, mean age 58 ± 10 SD and 61 ± 10 SD years, respectively). Cirrhosis was due to alcohol abuse (n = 169), chronic infection with hepatitis B virus (n = 31) or non-A, non-B hepatitis virus (NANBV; n = 107, including 75 positive for anti-hepatitis C virus), concomitant chronic hepatitis B virus or NANBV infection and alcohol abuse (n = 50), and miscellaneous causes (n = 43). At enrolment, 231 patients were classified as having Child's class A cirrhosis, 130 as B and 39 as C. Statistical analysis: The cumulative probability of developing gallstones was estimated by the Kaplan-Meier method and possible risk factors evaluated by logistic regression analysis. Results: During a median follow-up of 48 months (range 12 to 132 months), ultrasonography demonstrated the development of gallstones in 94 patients (23.5%, 53 men and 41 women), who were all informed of the finding. The proportion of symptomatic patients was 10% at diagnosis, whereas 16.2% manifested gallstone-related symptoms during follow-up. Cholecystectomy was carried out in three patients. The cumulative probability of gallstone development was 15 and 38% at 4 and 8 years, respectively. On logistic regression analysis, high body mass index, female gender and severity of liver disease were significantly associated with a higher risk of cholelithiasis. Conclusion: This longitudinal study provides further evidence of the clinical importance of gallstones in cirrhosis, already demonstrated in prevalence studies.
| Original language | English |
|---|---|
| Pages (from-to) | 55-58 |
| Number of pages | 4 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 6 |
| Issue number | 1 |
| Publication status | Published - 1994 |
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Keywords
- Cirrhosis
- Gallstones
ASJC Scopus subject areas
- Gastroenterology
Cite this
Probability of developing gallstones and related risk factors in 400 cirrhotics. / Conte, D.; Fraquelli, M.; Mandelli, C.; Braga, M.; Casarin, P.; Bodini, P.; Aimo, G. P.; Borzio, M.; Barisani, D.
In: European Journal of Gastroenterology and Hepatology, Vol. 6, No. 1, 1994, p. 55-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Probability of developing gallstones and related risk factors in 400 cirrhotics
AU - Conte, D.
AU - Fraquelli, M.
AU - Mandelli, C.
AU - Braga, M.
AU - Casarin, P.
AU - Bodini, P.
AU - Aimo, G. P.
AU - Borzio, M.
AU - Barisani, D.
PY - 1994
Y1 - 1994
N2 - Objective: To estimate the cumulative probability of developing gallstones and to evaluate possible risk factors in a large series of Italian cirrhotic patients, free of gallstones at enrolment. Setting: Gastroenterology unit at a Milan teaching hospital and four general hospitals in northern Italy. Patients: The study included 400 consecutive cirrhotic patients (257 men and 143 women, mean age 58 ± 10 SD and 61 ± 10 SD years, respectively). Cirrhosis was due to alcohol abuse (n = 169), chronic infection with hepatitis B virus (n = 31) or non-A, non-B hepatitis virus (NANBV; n = 107, including 75 positive for anti-hepatitis C virus), concomitant chronic hepatitis B virus or NANBV infection and alcohol abuse (n = 50), and miscellaneous causes (n = 43). At enrolment, 231 patients were classified as having Child's class A cirrhosis, 130 as B and 39 as C. Statistical analysis: The cumulative probability of developing gallstones was estimated by the Kaplan-Meier method and possible risk factors evaluated by logistic regression analysis. Results: During a median follow-up of 48 months (range 12 to 132 months), ultrasonography demonstrated the development of gallstones in 94 patients (23.5%, 53 men and 41 women), who were all informed of the finding. The proportion of symptomatic patients was 10% at diagnosis, whereas 16.2% manifested gallstone-related symptoms during follow-up. Cholecystectomy was carried out in three patients. The cumulative probability of gallstone development was 15 and 38% at 4 and 8 years, respectively. On logistic regression analysis, high body mass index, female gender and severity of liver disease were significantly associated with a higher risk of cholelithiasis. Conclusion: This longitudinal study provides further evidence of the clinical importance of gallstones in cirrhosis, already demonstrated in prevalence studies.
AB - Objective: To estimate the cumulative probability of developing gallstones and to evaluate possible risk factors in a large series of Italian cirrhotic patients, free of gallstones at enrolment. Setting: Gastroenterology unit at a Milan teaching hospital and four general hospitals in northern Italy. Patients: The study included 400 consecutive cirrhotic patients (257 men and 143 women, mean age 58 ± 10 SD and 61 ± 10 SD years, respectively). Cirrhosis was due to alcohol abuse (n = 169), chronic infection with hepatitis B virus (n = 31) or non-A, non-B hepatitis virus (NANBV; n = 107, including 75 positive for anti-hepatitis C virus), concomitant chronic hepatitis B virus or NANBV infection and alcohol abuse (n = 50), and miscellaneous causes (n = 43). At enrolment, 231 patients were classified as having Child's class A cirrhosis, 130 as B and 39 as C. Statistical analysis: The cumulative probability of developing gallstones was estimated by the Kaplan-Meier method and possible risk factors evaluated by logistic regression analysis. Results: During a median follow-up of 48 months (range 12 to 132 months), ultrasonography demonstrated the development of gallstones in 94 patients (23.5%, 53 men and 41 women), who were all informed of the finding. The proportion of symptomatic patients was 10% at diagnosis, whereas 16.2% manifested gallstone-related symptoms during follow-up. Cholecystectomy was carried out in three patients. The cumulative probability of gallstone development was 15 and 38% at 4 and 8 years, respectively. On logistic regression analysis, high body mass index, female gender and severity of liver disease were significantly associated with a higher risk of cholelithiasis. Conclusion: This longitudinal study provides further evidence of the clinical importance of gallstones in cirrhosis, already demonstrated in prevalence studies.
KW - Cirrhosis
KW - Gallstones
UR - http://www.scopus.com/inward/record.url?scp=0028107474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028107474&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028107474
VL - 6
SP - 55
EP - 58
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 1
ER -