Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation

Renato Cannizzaro, Stefania Maiero, Mara Fornasarig, Vincenzo Canzonieri, Raffaella Magris, Giovanni Guarnieri, Martina Urbani, Angela Buonadonna, Tanja Baresic, Paola Spessotto

Research output: Contribution to journalArticlepeer-review

Abstract

The potential role of the probe-based confocal laser endomicroscopy (pCLE) has been analyzed in different pathologic conditions of the gastrointestinal tract. Here, we analyzed a case of extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) using, for the first time, the pCLE system. A 72-year old man was diagnosed with an 8 cm diameter rectal HGNEC by standard colonoscopy integrated with the pCLE system. The diagnosis of neuroendocrine carcinoma was confirmed by immunohistochemical analyses. By using the pCLE system, we well defined and resolved vascular structures and mucosal architecture. An altered mucosal pattern and vascular defects, peculiar for HGNEC, were observed at high magnification, allowing the identification of a pattern which was quite different from that observed in poorly differentiated adenocarcinomas (PDA) where tissues appear darker, very irregular, even if glandular structures can still be recognized. This underlines the usefulness of pCLE in discriminating HGNECs from PDAs. In conclusion, pCLE could represent a valid and helpful method for in vivo HGNEC diagnosis, allowing prompt and careful management of the patient.

Original languageEnglish
Pages (from-to)4577-4583
Number of pages7
JournalOncoTargets and Therapy
Volume12
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Extrapulmonary high grade neuroendocrine carcinoma
  • Neoangiogenesis
  • Poorly differentiated adenocarcinoma
  • Probe-based confocal endomicroscopy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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