TY - JOUR
T1 - Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation
AU - Cannizzaro, Renato
AU - Maiero, Stefania
AU - Fornasarig, Mara
AU - Canzonieri, Vincenzo
AU - Magris, Raffaella
AU - Guarnieri, Giovanni
AU - Urbani, Martina
AU - Buonadonna, Angela
AU - Baresic, Tanja
AU - Spessotto, Paola
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The potential role of the probe-based confocal laser endomicroscopy (pCLE) has been analyzed in different pathologic conditions of the gastrointestinal tract. Here, we analyzed a case of extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) using, for the first time, the pCLE system. A 72-year old man was diagnosed with an 8 cm diameter rectal HGNEC by standard colonoscopy integrated with the pCLE system. The diagnosis of neuroendocrine carcinoma was confirmed by immunohistochemical analyses. By using the pCLE system, we well defined and resolved vascular structures and mucosal architecture. An altered mucosal pattern and vascular defects, peculiar for HGNEC, were observed at high magnification, allowing the identification of a pattern which was quite different from that observed in poorly differentiated adenocarcinomas (PDA) where tissues appear darker, very irregular, even if glandular structures can still be recognized. This underlines the usefulness of pCLE in discriminating HGNECs from PDAs. In conclusion, pCLE could represent a valid and helpful method for in vivo HGNEC diagnosis, allowing prompt and careful management of the patient.
AB - The potential role of the probe-based confocal laser endomicroscopy (pCLE) has been analyzed in different pathologic conditions of the gastrointestinal tract. Here, we analyzed a case of extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) using, for the first time, the pCLE system. A 72-year old man was diagnosed with an 8 cm diameter rectal HGNEC by standard colonoscopy integrated with the pCLE system. The diagnosis of neuroendocrine carcinoma was confirmed by immunohistochemical analyses. By using the pCLE system, we well defined and resolved vascular structures and mucosal architecture. An altered mucosal pattern and vascular defects, peculiar for HGNEC, were observed at high magnification, allowing the identification of a pattern which was quite different from that observed in poorly differentiated adenocarcinomas (PDA) where tissues appear darker, very irregular, even if glandular structures can still be recognized. This underlines the usefulness of pCLE in discriminating HGNECs from PDAs. In conclusion, pCLE could represent a valid and helpful method for in vivo HGNEC diagnosis, allowing prompt and careful management of the patient.
KW - Extrapulmonary high grade neuroendocrine carcinoma
KW - Neoangiogenesis
KW - Poorly differentiated adenocarcinoma
KW - Probe-based confocal endomicroscopy
UR - http://www.scopus.com/inward/record.url?scp=85069805706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069805706&partnerID=8YFLogxK
U2 - 10.2147/OTT.S198034
DO - 10.2147/OTT.S198034
M3 - Article
AN - SCOPUS:85069805706
VL - 12
SP - 4577
EP - 4583
JO - OncoTargets and Therapy
JF - OncoTargets and Therapy
SN - 1178-6930
ER -